Research + Discoveries

Uncoupling Protein–Protein Interactions from Enzyme Catalysis

Researchers in the McCafferty Lab have recently designed a mutant enzyme that shows promise as a molecular probe. This engineered enzyme is a mutant of lysine–specific demethylase 1A (KDM1A/LSD1), an epigenetic target with therapeutic potential. The researchers removed a protein interaction domain from KDM1A and replaced it with the corresponding region of a closely related enzyme. This molecular tool will allow users to effectively study the protein–protein interactions of KDM1A. Read more here.