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Malcolmson Lab Reports Catalytic Enantioselective Intermolecular Hydroamination

The development of reactions that transform cheap and readily accessible materials to high-value products with minimal waste is an important objective in chemical synthesis.  Enantioselective intermolecular olefin hydrofunctionalizations meet these criteria but are rare.  The Malcolmson lab has reported the first examples of late transition metal-catalyzed enantioselective intermolecular hydroamination of olefins with aliphatic amines.  A range of acyclic 1,3-dienes undergo reaction with several amines in the presence of a Pd catalyst to deliver highly enantioenriched allylic amines.  Read more about this method in The Journal of the American Chemical Society, available here.