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Hargrove Lab Hopes to Expedite the Discovery of RNA-targeted Ligands

Non-coding RNAs have been identified that are essential for cellular regulation and that are misregulated in disease; however, the development of tools to study these RNAs has been challenging. To harness existing knowledge into the development of RNA-targeted chemical probes, the Hargrove lab examined the RNA targets, design and discovery strategies, and characterization techniques for ligands in the RNA-targeted BIoactive ligaNd Database (R-BIND).  Further, the survey details the applicability of current tools to identify and evaluate RNA-targeted chemical probes, suggests criteria to assess the quality of RNA chemical probes and targets, and proposes areas where new tools are particularly needed. Learn more about current and future RNA-targeted chemical probe discovery in Nucleic Acids Research, available here.

 

Morgan