Overview
Paul Modrich, James B. Duke Professor of Biochemistry, was awarded the 2015 Nobel Prize for Chemistry along with Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in the UK, and Aziz Sancar of University of North Carolina, Chapel Hill, for mechanistic studies of DNA repair.
Mismatch repair is a mutation avoidance system that stabilizes the genome by correcting DNA biosynthetic errors, by blocking recombination between diverged DNA sequences, and in the case of human cells, …
Mismatch repair is a mutation avoidance system that stabilizes the genome by correcting DNA biosynthetic errors, by blocking recombination between diverged DNA sequences, and in the case of human cells, …
Current Appointments & Affiliations
James B. Duke Distinguished Professor Emeritus of Biochemistry
·
2022 - Present
Biochemistry,
Basic Science Departments
Professor Emeritus of Biochemistry
·
2022 - Present
Biochemistry,
Basic Science Departments
Professor of Chemistry
·
2015 - Present
Chemistry,
Trinity College of Arts & Sciences
In the News
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Recent Publications
Mechanisms in E. Coli and human mismatch repair
Chapter · February 15, 2022 CiteHuman MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Journal Article Proc Natl Acad Sci U S A · February 18, 2020 MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1-MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this dele ... Full text Link to item CiteThe mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.
Journal Article Proc Natl Acad Sci U S A · July 10, 2018 MutLα (MLH1-PMS2 heterodimer), which acts as a strand-directed endonuclease during the initiation of eukaryotic mismatch repair, has been postulated to function as a zinc-dependent enzyme [Kosinski J, Plotz G, Guarné A, Bujnicki JM, Friedhoff P (2008) J Mo ... Full text Link to item CiteRecent Grants
Enzymology Of Eukaryotic Mismatch Repair
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1991 - 2019Forces and Long-Distance Coupling along DNA in the Mismatch Repair (MMR) Pathway
FellowshipMentor · Awarded by National Institutes of Health · 2014 - 2016Clinical Oncology Research Career Development Program
ResearchMentor · Awarded by National Institutes of Health · 2009 - 2015View All Grants
Education, Training & Certifications
Stanford University ·
1973
Ph.D.
Massachusetts Institute of Technology ·
1968
B.S.