Faculty Profiles

Ashutosh Chilkoti
Alan L. Kaganov Professor of Biomedical Engineering
1427 CIEMAS, Durham, NC 27708
(919) 660-5373
+1 919 660 5409



Ph.D., University of Washington 1991

Mastria, EM, Cai, LY, Kan, MJ, Li, X, Schaal, JL, Fiering, S, Gunn, MD, Dewhirst, MW, Nair, SK, and Chilkoti, A. "Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity." Journal of controlled release : official journal of the Controlled Release Society 269 (January 2018): 364-373. Full Text

Costa, SA, Simon, JR, Amiram, M, Tang, L, Zauscher, S, Brustad, EM, Isaacs, FJ, and Chilkoti, A. "Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides." Advanced materials (Deerfield Beach, Fla.) (December 11, 2017). Full Text

Luginbuhl, KM, Mozhdehi, D, Dzuricky, M, Yousefpour, P, Huang, FC, Mayne, NR, Buehne, KL, and Chilkoti, A. "Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs." Angewandte Chemie (International ed. in English) 56.45 (November 2017): 13979-13984. Full Text

Wang, J, Dzuricky, M, and Chilkoti, A. "The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles." Nano letters 17.10 (October 2017): 5995-6005. Full Text

Bhattacharyya, J, Ren, X-R, Mook, RA, Wang, J, Spasojevic, I, Premont, RT, Li, X, Chilkoti, A, and Chen, W. "Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth." Nanoscale 9.34 (August 22, 2017): 12709-12717. Full Text

Joh, DY, Hucknall, AM, Wei, Q, Mason, KA, Lund, ML, Fontes, CM, Hill, RT, Blair, R, Zimmers, Z, Achar, RK, Tseng, D, Gordan, R, Freemark, M, Ozcan, A, and Chilkoti, A. "Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood." Proceedings of the National Academy of Sciences of the United States of America 114.34 (August 7, 2017): E7054-E7062. Full Text

Wang, J, Bhattacharyya, J, Mastria, E, and Chilkoti, A. "A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles." Journal of controlled release : official journal of the Controlled Release Society 260 (August 2017): 100-110. Full Text

Weitzhandler, I, Dzuricky, M, Hoffmann, I, Garcia Quiroz, F, Gradzielski, M, and Chilkoti, A. "Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides." Biomacromolecules 18.8 (August 2017): 2419-2426. Full Text

Tang, L, Navarro, LA, Chilkoti, A, and Zauscher, S. "High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation." Angewandte Chemie (International ed. in English) 56.24 (June 2017): 6778-6782. Full Text

MacEwan, SR, and Chilkoti, A. "From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers." Angewandte Chemie (International ed. in English) 56.24 (June 2017): 6712-6733. (Review) Full Text


Bhattacharyya, J, Bellucci, JJ, and Chilkoti, A. "Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering." Biomaterials from Nature for Advanced Devices and Therapies. January 1, 2016. 106-126. Full Text

Hill, RT, and Chilkoti, A. "Surface Patterning." Biomaterials Science: An Introduction to Materials: Third Edition. January 1, 2013. 276-301. Full Text

Nusz, G, and Chilkoti, A. "Individual plasmonic nanostructures as label free biosensors." Nanoplasmonic Sensors. January 1, 2012. 105-126. Full Text

Liu, W, Mukerji, R, Li, X, Schaal, J, Bhattacharyya, J, Zalutsky, M, and Chilkoti, A. "Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor." October 1, 2014. Full Text

Quiroz, FG, and Chilkoti, A. "The language of protein polymers." January 1, 2014. Full Text

Tang, L, Tjong, V, Gu, R, Chilkoti, A, and Zauscher, S. "Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles." September 8, 2013.

Garanger, E, Mac Ewan, S, Brulet, A, Bataille, L, Sandre, O, Chilkoti, A, and Lecommandoux, S. "Elastin-based amphiphilic copolymers as precision building blocks for controlled self-assembly." September 8, 2013.

Weinberger, A, Macewan, S, Schmatko, T, Schroder, A, Chilkoti, A, and Marques, CM. "Interactions of elastin-like polypeptides with model membranes on GUVs." July 2013.