Faculty Profiles

Jiyong Hong
Professor of Chemistry
3220 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1545
(919) 660-1605



Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University 1995

B.S., Seoul National University 1993

Research Areas:
Synthesis, Biological, Organic

Siska, PJ, Beckermann, KE, Mason, FM, Andrejeva, G, Greenplate, AR, Sendor, AB, Chiang, Y-CJ, Corona, AL, Gemta, LF, Vincent, BG, Wang, RC, Kim, B, Hong, J, Chen, C-L, Bullock, TN, Irish, JM, Rathmell, WK, and Rathmell, JC. "Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma." JCI insight 2.12 (June 15, 2017). Full Text

Kim, B, Ratnayake, R, Lee, H, Shi, G, Zeller, SL, Li, C, Luesch, H, and Hong, J. "Synthesis and biological evaluation of largazole zinc-binding group analogs." Bioorganic & medicinal chemistry 25.12 (June 2017): 3077-3086. Full Text

Lanier, ML, Park, H, Mukherjee, P, Timmerman, JC, Ribeiro, AA, Widenhoefer, RA, and Hong, J. "Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation." Chemistry (Weinheim an der Bergstrasse, Germany) 23.30 (May 2017): 7180-7184. Full Text

Siska, PJ, Kim, B, Ji, X, Hoeksema, MD, Massion, PP, Beckermann, KE, Wu, J, Chi, J-T, Hong, J, and Rathmell, JC. "Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes." Journal of immunological methods 438 (November 2016): 51-58. Full Text

Lee, K, Lanier, ML, Kwak, J-H, Kim, H, and Hong, J. "Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A." Natural product reports 33.12 (November 2016): 1393-1424. (Review) Full Text

Geer Wallace, MA, Kwon, D-Y, Weitzel, DH, Lee, C-T, Stephenson, TN, Chi, J-T, Mook, RA, Dewhirst, MW, Hong, J, and Fitzgerald, MC. "Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements." Journal of proteome research 15.8 (August 2016): 2688-2696. Full Text

Chung, BC, Mashalidis, EH, Tanino, T, Kim, M, Matsuda, A, Hong, J, Ichikawa, S, and Lee, S-Y. "Structural insights into inhibition of lipid I production in bacterial cell wall synthesis." Nature 533.7604 (May 2016): 557-560. Full Text

Kwon, D-Y, Lee, HE, Weitzel, DH, Park, K, Lee, SH, Lee, C-T, Stephenson, TN, Park, H, Fitzgerald, MC, Chi, J-T, Mook, RA, Dewhirst, MW, Lee, YM, and Hong, J. "Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition." Journal of medicinal chemistry 58.19 (October 2015): 7659-7671. Full Text

Baker, JB, Kim, H, and Hong, J. "Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction." Tetrahedron letters 56.23 (June 2015): 3120-3122. Full Text

Lim, W, Park, J, Lee, YH, Hong, J, and Lee, Y. "Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist." Biochemical and biophysical research communications 461.3 (June 2015): 507-512. Full Text


Toone, EJ. Preface. December 1, 2011.

Garbaccio, RM, Johnson, DS, Hong, J, and Disney, MD. "Preface." November 2015. 4714-. Full Text

Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 2014. Full Text

Lee, K, Kim, H, and Hong, J. "Stereoselective formal synthesis of leucascandrolide A." August 28, 2011.

Harrington, JM, Park, H, Ying, Y, Hong, J, and Crumbliss, AL. "Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A." August 16, 2009.

Ying, Y, Kim, H, Taori, K, Luesch, H, and Hong, J. "ORGN 523-Total synthesis of largazole." August 17, 2008.