Hargrove Group

Research

Summary

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “Wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

 

Affiliations:

Structural Biology and Biophysics Program
Pharmacology Sciences Training Program
Duke Program in Cell and Molecular Biology
Duke BioCoRE Program

Duke Center for RNA Biology
Duke Cancer Institute
Fitzpatrick Institute for Photonics
Duke Center for AIDS Research
Center for Biomolecular and Tissue Engineering

Collaborations
Al-Hashimi Lab, Duke Biochemistry
Oak Ridge National Lab
 
Funding
Duke University
NIH (Center for HIV RNA Studies)
Ralph A. Powe Award (ORAU)
Prostate Cancer Foundation (Young Investigator Award)
DOD CDMRP Prostate Cancer Research Program
Cottrell Scholar Award
 
Student and Postdoc Funding and Awards
NIH Structural Biology and Biophysics Program
Burroughs-Wellcome Fellowship in Organic Chemistry (Duke Chem Dept)
Duke Center for RNA Biology Travel Award
Dean’s Summer Research Fellowship
Gordon Research Fellowship 
Undergraduate Research Support Independent Study Grant
NIH T32 Ruth L. Kirschstein Training Grant Fellowship
Center for Biomolecular and Tissue Engineering Training Program Lew Fellowship
GAAN Fellowship
Undergraduate Research Support Assistantship Grant
Undergraduate Research Support Travel Grant
Katherine Goodman Stern Fellowship