M.D., Columbia University 1966
Liu, X, Ahn, S, Kahsai, AW, Meng, K-C, Latorraca, NR, Pani, B, Venkatakrishnan, AJ, Masoudi, A, Weis, WI, Dror, RO, Chen, X, Lefkowitz, RJ, and Kobilka, BK. "Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure." Nature 548.7668 (August 16, 2017): 480-484. Full Text
Cahill, TJ, Thomsen, ARB, Tarrasch, JT, Plouffe, B, Nguyen, AH, Yang, F, Huang, L-Y, Kahsai, AW, Bassoni, DL, Gavino, BJ, Lamerdin, JE, Triest, S, Shukla, AK, Berger, B, Little, J, Antar, A, Blanc, A, Qu, C-X, Chen, X, Kawakami, K, Inoue, A, Aoki, J, Steyaert, J, Sun, J-P, Bouvier, M, Skiniotis, G, and Lefkowitz, RJ. "Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis." Proceedings of the National Academy of Sciences of the United States of America 114.10 (March 2017): 2562-2567. Full Text
Stoppel, LJ, Auerbach, BD, Senter, RK, Preza, AR, Lefkowitz, RJ, and Bear, MF. "β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X." Cell reports 18.12 (March 2017): 2807-2814. Full Text
Ahn, S, Kahsai, AW, Pani, B, Wang, Q-T, Zhao, S, Wall, AL, Strachan, RT, Staus, DP, Wingler, LM, Sun, LD, Sinnaeve, J, Choi, M, Cho, T, Xu, TT, Hansen, GM, Burnett, MB, Lamerdin, JE, Bassoni, DL, Gavino, BJ, Husemoen, G, Olsen, EK, Franch, T, Costanzi, S, Chen, X, and Lefkowitz, RJ. "Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library." Proceedings of the National Academy of Sciences of the United States of America 114.7 (February 2017): 1708-1713. Full Text
Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature chemical biology 12.9 (September 2016): 709-716. Full Text
Thomsen, ARB, Plouffe, B, Cahill, TJ, Shukla, AK, Tarrasch, JT, Dosey, AM, Kahsai, AW, Strachan, RT, Pani, B, Mahoney, JP, Huang, L, Breton, B, Heydenreich, FM, Sunahara, RK, Skiniotis, G, Bouvier, M, and Lefkowitz, RJ. "GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling." Cell 166.4 (August 3, 2016): 907-919. Full Text
Staus, DP, Strachan, RT, Manglik, A, Pani, B, Kahsai, AW, Kim, TH, Wingler, LM, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, AC, Pardon, E, Steyaert, J, Weis, WI, Prosser, RS, Kobilka, BK, Costa, T, and Lefkowitz, RJ. "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation." Nature 535.7612 (July 13, 2016): 448-452. Full Text
Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American journal of physiology. Heart and circulatory physiology 309.9 (November 2015): H1516-H1527. Full Text
Lefkowitz, RJ, Mukherjee, C, and Caron, M. Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists. January 1, 1977.
Rein, LAM, Wisler, JW, Theriot, BS, Huang, L-Y, Premont, RT, and Lefkowitz, RJ. "beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis." December 3, 2015.
Shukla, AK, Manglik, A, Kruse, A, Reis, R, Tseng, WC, Staus, DP, Hilger, D, Uysal, S, Huang, L, Peduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AK, Kobilka, BK, and Lefkowitz, RJ. "Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor." April 2013.
Maudsley, S, Liao, S, Yuan, L, Lefkowitz, RJ, Luttrell, LM, and Gesty-Palmer, D. "The Unique Efficacy Profile of a beta-Arrestin Pathway-Selective Parathyroid Hormone Receptor Agonist Revealed by Metabolic Pathways Analysis." June 2010.
Patel, CB, Patel, PA, Frangakis, SG, Chen, M, Shenoy, SK, Lefkowitz, RJ, and Rockman, HA. "A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation." November 3, 2009.
Wang, J, Liu, R, Bond, M, Chen, M, Singh, S, Ali-Osman, F, Lefkowitz, RJ, Diehl, AM, Lyerly, HK, Barak, L, and Chen, W. "Targeting hedgehog signaling in medulloblastoma." October 2007.
Lefkowitz, RJ. "Seven transmembrane receptors: something old, something new." May 2007. Full Text
Chen, J, Naga Prasad, SV, Tilley, DG, Lefkowitz, RJ, and Rockman, HA. "beta-arrestin mediated beta 1-adrenergic receptor transactivartion of the epidermal growth factor receptor requires GRK 5 and 6." October 31, 2006.
Kim, J, Zhang, L, Peppel, K, Lefkowitz, RJ, and Freedman, NJ. "beta-arrestins regulate proliferation and migration of smooth muscle cells in vitro & in vivo: Isoform-specific roles." October 31, 2006.
Shenoy, SK, and Lefkowitz, RJ. "Beta-arrestin-dependent signaling by seven-transmembrane receptors." August 30, 2006.
Nobles, KN, Guan, ZQ, Xiao, KH, Oas, TG, and Lefkowitz, RJ. "Conformational changes in beta-arrestin1: The importance of beta-arrestin1's N-domain." March 6, 2006.
Koch, WJ, Rockman, HA, Samama, P, Hamilton, RA, Bond, RA, Milano, CA, and Lefkowitz, RJ. "Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor." Circulation 92.3 (1995): 277--.