Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Lefkowitz, RJ, Rajagopal, K, and Whalen, EJ. "New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors." Mol Cell 24.5 (December 8, 2006): 643-652. (Review) Full Text

Violin, JD, Dewire, SM, Barnes, WG, and Lefkowitz, RJ. "G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics." J Biol Chem 281.47 (November 24, 2006): 36411-36419. Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103.44 (October 31, 2006): 16284-16289. Full Text

Meloni, AR, Fralish, GB, Kelly, P, Salahpour, A, Chen, JK, Wechsler-Reya, RJ, Lefkowitz, RJ, and Caron, MG. "Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2." Mol Cell Biol 26.20 (October 2006): 7550-7560. Full Text Open Access Copy

Drake, MT, Shenoy, SK, and Lefkowitz, RJ. "Trafficking of G protein-coupled receptors." Circ Res 99.6 (September 15, 2006): 570-582. Full Text Open Access Copy

Reiter, E, and Lefkowitz, RJ. "GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling." Trends Endocrinol Metab 17.4 (May 2006): 159-165. (Review) Full Text

Gesty-Palmer, D, Chen, M, Reiter, E, Ahn, S, Nelson, CD, Wang, S, Eckhardt, AE, Cowan, CL, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation." J Biol Chem 281.16 (April 21, 2006): 10856-10864. Full Text

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, K, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor." J Biol Chem 281.2 (January 13, 2006): 1261-1273. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Receptor regulation: β-arrestin moves up a notch." Nature Cell Biology 7.12 (December 2005): 1159-1161. Full Text

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