Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Violin, JD, DiPilato, LM, Yildirim, N, Elston, TC, Zhang, J, and Lefkowitz, RJ. "beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics." The Journal of Biological Chemistry 283.5 (February 2008): 2949-2961. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on Behavior." CELL 132.1 (January 11, 2008): 125-136. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on behavior." Cell 132.1 (January 2008): 125-136. Full Text

Wisler, JW, DeWire, SM, Whalen, EJ, Violin, JD, Drake, MT, Ahn, S, Shenoy, SK, and Lefkowitz, RJ. "A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling." Proceedings of the National Academy of Sciences of the United States of America 104.42 (October 9, 2007): 16657-16662. Full Text

Shenoy, SK, Barak, LS, Xiao, K, Ahn, S, Berthouze, M, Shukla, AK, Luttrell, LM, and Lefkowitz, RJ. "Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation." The Journal of Biological Chemistry 282.40 (October 2007): 29549-29562. Full Text

Noma, T, Lemaire, A, Naga Prasad, SV, Barki-Harrington, L, Tilley, DG, Chen, J, Le Corvoisier, P, Violin, JD, Wei, H, Lefkowitz, RJ, and Rockman, HA. "Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection." The Journal of Clinical Investigation 117.9 (September 2007): 2445-2458. Full Text Open Access Copy

Violin, JD, and Lefkowitz, RJ. "Beta-arrestin-biased ligands at seven-transmembrane receptors." Trends in Pharmacological Sciences 28.8 (August 2007): 416-422. (Review) Full Text

Xiao, K, McClatchy, DB, Shukla, AK, Zhao, Y, Chen, M, Shenoy, SK, Yates, JR, and Lefkowitz, RJ. "Functional specialization of beta-arrestin interactions revealed by proteomic analysis." Proceedings of the National Academy of Sciences of the United States of America 104.29 (July 9, 2007): 12011-12016. Full Text

Nobles, KN, Guan, Z, Xiao, K, Oas, TG, and Lefkowitz, RJ. "The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2." The Journal of Biological Chemistry 282.29 (July 2007): 21370-21381. Full Text

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129.3 (May 4, 2007): 511-522. Full Text

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