Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Noma, T, Lemaire, A, Naga Prasad, SV, Barki-Harrington, L, Tilley, DG, Chen, J, Le Corvoisier, P, Violin, JD, Wei, H, Lefkowitz, RJ, and Rockman, HA. "Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection." J Clin Invest 117.9 (September 2007): 2445-2458. Full Text Open Access Copy

Violin, JD, and Lefkowitz, RJ. "Beta-arrestin-biased ligands at seven-transmembrane receptors." Trends Pharmacol Sci 28.8 (August 2007): 416-422. (Review) Full Text

Xiao, K, McClatchy, DB, Shukla, AK, Zhao, Y, Chen, M, Shenoy, SK, Yates, JR, and Lefkowitz, RJ. "Functional specialization of beta-arrestin interactions revealed by proteomic analysis." Proc Natl Acad Sci U S A 104.29 (July 17, 2007): 12011-12016. Full Text

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129.3 (May 4, 2007): 511-522. Full Text

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." CELL 129.3 (May 4, 2007): 511-522. Full Text

Lefkowitz, RJ. "Seven transmembrane receptors: something old, something new." Acta Physiol (Oxf) 190.1 (May 2007): 9-19. (Review) Full Text

Girnita, L, Shenoy, SK, Sehat, B, Vasilcanu, R, Vasilcanu, D, Girnita, A, Lefkowitz, RJ, and Larsson, O. "Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression." J Biol Chem 282.15 (April 13, 2007): 11329-11338. Full Text

Lefkowitz, RJ. "Seven transmembrane receptors: a brief personal retrospective." Biochim Biophys Acta 1768.4 (April 2007): 748-755. Full Text

Nelson, CD, Perry, SJ, Regier, DS, Prescott, SM, Topham, MK, and Lefkowitz, RJ. "Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins." Science 315.5812 (February 2, 2007): 663-666. Full Text

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