Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

DeWire, SM, Kim, J, Whalen, EJ, Ahn, S, Chen, M, and Lefkowitz, RJ. "Beta-arrestin-mediated signaling regulates protein synthesis." J Biol Chem 283.16 (April 18, 2008): 10611-10620. Full Text

Lefkowitz, RJ. "The annual ASCI meeting: does nostalgia have a future?." J Clin Invest 118.4 (April 2008): 1231-1233. Full Text Open Access Copy

Drake, MT, Violin, JD, Whalen, EJ, Wisler, JW, Shenoy, SK, and Lefkowitz, RJ. "beta-arrestin-biased agonism at the beta2-adrenergic receptor." J Biol Chem 283.9 (February 29, 2008): 5669-5676. Full Text

Lefkowitz, RJ, Sun, J-P, and Shukla, AK. "A crystal clear view of the beta2-adrenergic receptor." Nat Biotechnol 26.2 (February 2008): 189-191. Full Text

Violin, JD, DiPilato, LM, Yildirim, N, Elston, TC, Zhang, J, and Lefkowitz, RJ. "beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics." J Biol Chem 283.5 (February 1, 2008): 2949-2961. Full Text

Violin, JD, DiPilato, LM, Yildirim, N, Elston, TC, Zhang, J, and Lefkowitz, RJ. "β2-Adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics." Journal of Biological Chemistry 283.5 (February 1, 2008): 2949-2961. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on behavior." Cell 132.1 (January 11, 2008): 125-136. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on Behavior." CELL 132.1 (January 11, 2008): 125-136. Full Text

Wisler, JW, DeWire, SM, Whalen, EJ, Violin, JD, Drake, MT, Ahn, S, Shenoy, SK, and Lefkowitz, RJ. "A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling." Proc Natl Acad Sci U S A 104.42 (October 16, 2007): 16657-16662. Full Text

Shenoy, SK, Barak, LS, Xiao, K, Ahn, S, Berthouze, M, Shukla, AK, Luttrell, LM, and Lefkowitz, RJ. "Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation." J Biol Chem 282.40 (October 5, 2007): 29549-29562. Full Text

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