Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Ahn, S, Kim, J, Hara, MR, Ren, X-R, and Lefkowitz, RJ. "{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation." J Biol Chem 284.13 (March 27, 2009): 8855-8865. Full Text

Tarrant, TK, Rampersad, RR, Esserman, D, Rothlein, LR, Liu, P, Premont, RT, Lefkowitz, RJ, Lee, DM, and Patel, DD. "Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)." Clin Immunol 129.1 (October 2008): 115-122. Full Text

Barak, LS, Salahpour, A, Zhang, X, Masri, B, Sotnikova, TD, Ramsey, AJ, Violin, JD, Lefkowitz, RJ, Caron, MG, and Gainetdinov, RR. "Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor." Mol Pharmacol 74.3 (September 2008): 585-594. Full Text

Ozawa, K, Whalen, EJ, Nelson, CD, Mu, Y, Hess, DT, Lefkowitz, RJ, and Stamler, JS. "S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking." Mol Cell 31.3 (August 8, 2008): 395-405. Full Text

Nelson, CD, Kovacs, JJ, Nobles, KN, Whalen, EJ, and Lefkowitz, RJ. "Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor." J Biol Chem 283.30 (July 25, 2008): 21093-21101. Full Text

Shukla, AK, Violin, JD, Whalen, EJ, Gesty-Palmer, D, Shenoy, SK, and Lefkowitz, RJ. "Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors." Proc Natl Acad Sci U S A 105.29 (July 22, 2008): 9988-9993. Full Text

Kim, J, Zhang, L, Peppel, K, Wu, J-H, Zidar, DA, Brian, L, DeWire, SM, Exum, ST, Lefkowitz, RJ, and Freedman, NJ. "Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration." Circ Res 103.1 (July 3, 2008): 70-79. Full Text Open Access Copy

Kovacs, JJ, Whalen, EJ, Liu, R, Xiao, K, Kim, J, Chen, M, Wang, J, Chen, W, and Lefkowitz, RJ. "Beta-arrestin-mediated localization of smoothened to the primary cilium." Science 320.5884 (June 27, 2008): 1777-1781. Full Text

Shukla, AK, Sun, J-P, and Lefkowitz, RJ. "Crystallizing thinking about the beta2-adrenergic receptor." Mol Pharmacol 73.5 (May 2008): 1333-1338. Full Text

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