Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Zidar, DA, Violin, JD, Whalen, EJ, and Lefkowitz, RJ. "Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands." Proc Natl Acad Sci U S A 106.24 (June 16, 2009): 9649-9654. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice." J Clin Invest 119.5 (May 2009): 1312-1321. Full Text Open Access Copy

Shenoy, SK, Modi, AS, Shukla, AK, Xiao, K, Berthouze, M, Ahn, S, Wilkinson, KD, Miller, WE, and Lefkowitz, RJ. "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." Proc Natl Acad Sci U S A 106.16 (April 21, 2009): 6650-6655. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "Beta-arrestin1 mediates nicotinic acid induced flushing, but not its antilipolytic effect." JOURNAL OF INVESTIGATIVE DERMATOLOGY 129 (April 2009): S1-S1.

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Liedtke, W, and Lefkowitz, RJ. "[beta]-arrestin 1 mediates angiotensin II induced ubiquitination and down-regulation of TRPV4." FASEB JOURNAL 23 (April 2009).

Ahn, S, Kim, J, Hara, MR, Ren, X-R, and Lefkowitz, RJ. "{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation." J Biol Chem 284.13 (March 27, 2009): 8855-8865. Full Text

Tarrant, TK, Rampersad, RR, Esserman, D, Rothlein, LR, Liu, P, Premont, RT, Lefkowitz, RJ, Lee, DM, and Patel, DD. "Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)." Clinical immunology (Orlando, Fla.) 129.1 (October 2008): 115-122. Full Text

Barak, LS, Salahpour, A, Zhang, X, Masri, B, Sotnikova, TD, Ramsey, AJ, Violin, JD, Lefkowitz, RJ, Caron, MG, and Gainetdinov, RR. "Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor." Mol Pharmacol 74.3 (September 2008): 585-594. Full Text

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