Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Gesty-Palmer, D, Nabel, B, Lefkowitz, RJ, and Kelner, KL. "Science Translational Medicine Podcast: 7 October 2009." Science Translational Medicine 1.1 (October 7, 2009): 1pc1-1pc1. Full Text

Gesty-Palmer, D, Flannery, P, Yuan, L, Corsino, L, Spurney, R, Lefkowitz, RJ, and Luttrell, LM. "A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation." Sci Transl Med 1.1 (October 7, 2009): 1ra1-. Full Text

Kovacs, JJ, Hara, MR, Davenport, CL, Kim, J, and Lefkowitz, RJ. "Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways." Dev Cell 17.4 (October 2009): 443-458. (Review) Full Text

Xie, L, Xiao, K, Whalen, EJ, Forrester, MT, Freeman, RS, Fong, G, Gygi, SP, Lefkowitz, RJ, and Stamler, JS. "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. (Published online)" Sci Signal 2.78 (July 7, 2009): ra33-. Full Text

Zidar, DA, Violin, JD, Whalen, EJ, and Lefkowitz, RJ. "Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands." Proc Natl Acad Sci U S A 106.24 (June 16, 2009): 9649-9654. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice." J Clin Invest 119.5 (May 2009): 1312-1321. Full Text

Shenoy, SK, Modi, AS, Shukla, AK, Xiao, K, Berthouze, M, Ahn, S, Wilkinson, KD, Miller, WE, and Lefkowitz, RJ. "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." Proc Natl Acad Sci U S A 106.16 (April 21, 2009): 6650-6655. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "Beta-arrestin1 mediates nicotinic acid induced flushing, but not its antilipolytic effect." JOURNAL OF INVESTIGATIVE DERMATOLOGY 129 (April 2009): S1-S1.

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Liedtke, W, and Lefkowitz, RJ. "[beta]-arrestin 1 mediates angiotensin II induced ubiquitination and down-regulation of TRPV4." FASEB JOURNAL 23 (April 2009).

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