Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Shukla, AK, Xiao, K, and Lefkowitz, RJ. "Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling." Trends in Biochemical Sciences 36.9 (September 2011): 457-469. (Review) Full Text

Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Molecular Pharmacology 80.3 (September 2011): 367-377. Full Text

Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor." Nature Chemical Biology 7.10 (August 21, 2011): 692-700. Full Text

Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1." Nature 477.7364 (August 21, 2011): 349-353. Full Text

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Science Signaling 4.185 (August 2011): ra51-null. Full Text

Rockman, HA, and Lefkowitz, RJ. "Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling." Circulation Research 109.2 (July 2011): 202-204. Full Text

Rajagopal, S, Kovacs, J, Badea, C, Johnson, GA, Rockman, HA, Piantadosi, CA, and Lefkowitz, RJ. "BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 57.14 (April 5, 2011): E2046-E2046. Full Text

Lovgren, AK, Kovacs, JJ, Xie, T, Potts, EN, Li, Y, Foster, WM, Liang, J, Meltzer, EB, Jiang, D, Lefkowitz, RJ, and Noble, PW. "β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix." Sci Transl Med 3.74 (March 16, 2011): 74ra23-. Full Text

Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends in Molecular Medicine 17.3 (March 2011): 126-139. (Review) Full Text

Kenakin, T, Agnati, LF, Caron, M, Fredholm, B, Guidoli, D, Kobilka, B, Lefkowitz, RW, Lohse, M, Woods, A, and Fuxe, K. "International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?." Journal of Receptor and Signal Transduction Research 30.5 (October 2010): 284-286. Full Text

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