Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends in molecular medicine 17.3 (March 2011): 126-139. (Review) Full Text

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Shenoy, SK, Liedtke, W, and Lefkowitz, RJ. "Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4." J Biol Chem 285.39 (September 24, 2010): 30115-30125. Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)." Proceedings of the National Academy of Sciences of the United States of America 107.34 (August 4, 2010): 15299-15304. Full Text

Rajagopal, S, Rajagopal, K, and Lefkowitz, RJ. "Teaching old receptors new tricks: biasing seven-transmembrane receptors." Nature reviews. Drug discovery 9.5 (May 2010): 373-386. (Review) Full Text

Rajagopal, S, Kim, J, Ahn, S, Craig, S, Lam, CM, Gerard, NP, Gerard, C, and Lefkowitz, RJ. "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7." Proc Natl Acad Sci U S A 107.2 (January 12, 2010): 628-632. Full Text

Kenakin, T, Agnati, LF, Caron, M, Fredholm, B, Guidoli, D, Kobilka, B, Lefkowitz, RW, Lohse, M, Woods, A, and Fuxe, K. "International workshop at the nobel forum, karolinska institutet on g protein-coupled receptors: Finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached." Journal of Receptors and Signal Transduction 30.5 (2010): 284-286. Full Text

Chen, M, Philipp, M, Wang, J, Premont, RT, Garrison, TR, Caron, MG, Lefkowitz, RJ, and Chen, W. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway." J Biol Chem 284.50 (December 11, 2009): 35040-35048. Full Text

Gesty-Palmer, D, Nabel, B, Lefkowitz, RJ, and Kelner, KL. "Science Translational Medicine Podcast: 7 October 2009." Science Translational Medicine 1.1 (October 7, 2009): 1pc1-1pc1. Full Text

Gesty-Palmer, D, Flannery, P, Yuan, L, Corsino, L, Spurney, R, Lefkowitz, RJ, and Luttrell, LM. "A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation." Sci Transl Med 1.1 (October 7, 2009): 1ra1-. Full Text

Kovacs, JJ, Hara, MR, Davenport, CL, Kim, J, and Lefkowitz, RJ. "Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways." Dev Cell 17.4 (October 2009): 443-458. (Review) Full Text

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