Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Lefkowitz, RJ. "A tale of two callings." J Clin Invest 121.10 (October 2011): 4201-4203. Full Text Open Access Copy

Shenoy, SK, and Lefkowitz, RJ. "β-Arrestin-mediated receptor trafficking and signal transduction." Trends Pharmacol Sci 32.9 (September 2011): 521-533. (Review) Full Text

Shukla, AK, Xiao, K, and Lefkowitz, RJ. "Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling." Trends Biochem Sci 36.9 (September 2011): 457-469. (Review) Full Text

Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Mol Pharmacol 80.3 (September 2011): 367-377. Full Text

Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor. (Published online)" Nat Chem Biol 7.10 (August 21, 2011): 692-700. Full Text

Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. (Published online)" Nature 477.7364 (August 21, 2011): 349-353. Full Text

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Sci Signal 4.185 (August 9, 2011): ra51-. Full Text

Rockman, HA, and Lefkowitz, RJ. "Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling." Circ Res 109.2 (July 8, 2011): 202-204. Full Text

Rajagopal, S, Kovacs, J, Badea, C, Johnson, GA, Rockman, HA, Piantadosi, CA, and Lefkowitz, RJ. "BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 57.14 (April 5, 2011): E2046-E2046.

Lovgren, AK, Kovacs, JJ, Xie, T, Potts, EN, Li, Y, Foster, WM, Liang, J, Meltzer, EB, Jiang, D, Lefkowitz, RJ, and Noble, PW. "β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix." Sci Transl Med 3.74 (March 16, 2011): 74ra23-. Full Text

Pages

LOMASNEY, JW, COTECCHIA, S, LORENZ, W, SCHWINN, DA, CARON, MG, and LEFKOWITZ, RJ. "STRUCTURE AND MOLECULAR CHARACTERIZATION OF ALPHA-ADRENERGIC RECEPTORS." 1991.

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