Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Lefkowitz, RJ. "Arrestins come of age: A personal historical perspective." Progress in Molecular Biology and Translational Science 118 (2013): 3-18. Full Text

Weiss, DR, Ahn, S, Sassano, MF, Kleist, A, Zhu, X, Strachan, R, Roth, BL, Lefkowitz, RJ, and Shoichet, BK. "Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor." ACS Chemical Biology 8.5 (2013): 1018-1026. Full Text

Fereshteh, M, Ito, T, Kovacs, JJ, Zhao, C, Kwon, HY, Tornini, V, Konuma, T, Chen, M, Lefkowitz, RJ, and Reya, T. "β-Arrestin2 mediates the initiation and progression of myeloid leukemia." Proc Natl Acad Sci U S A 109.31 (July 31, 2012): 12532-12537. Full Text

Heitzler, D, Durand, G, Gallay, N, Rizk, A, Ahn, S, Kim, J, Violin, JD, Dupuy, L, Gauthier, C, Piketty, V, Crépieux, P, Poupon, A, Clément, F, Fages, F, Lefkowitz, RJ, and Reiter, E. "Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. (Published online)" Mol Syst Biol 8 (June 26, 2012): 590-. Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)." Proceedings of the National Academy of Sciences of the United States of America 109.33 (2012): 13464--. Full Text

Reiter, E, Ahn, S, Shukla, AK, and Lefkowitz, RJ. "Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors." Annu Rev Pharmacol Toxicol 52 (2012): 179-197. (Review) Full Text

Lefkowitz, RJ, and VanHook, AM. "Science Signaling Podcast: 20 November 2012." Science Signaling 5.251 (2012). Full Text

Lefkowitz, RJ. "An interview with Robert J. Lefkowitz." Trends in pharmacological sciences 33.2 (2012): 51-52.

Lefkowitz, R, and Kobilka, B. "A signal honour." Chemistry World 9.11 (2012): 46-49.

Lefkowitz, RJ. "A tale of two callings." J Clin Invest 121.10 (October 2011): 4201-4203. Full Text Open Access Copy

Pages

Maurice, JP, Hata, JA, Shah, AS, Wilson, KH, McDonald, PH, Lefkowitz, RJ, Glower, DD, and Koch, WJ. "Global myocardial overpression of beta(2)-adrenergic receptors via intracoronary adenovirus delivery enhances in vivo contractility." October 27, 1998.

Kypson, AP, Akhter, SA, Peppel, K, Hendrickson, SC, McDonald, P, Lilly, RE, Glower, DD, Lefkowitz, RJ, and Koch, WJ. "Adenoviral-mediated gene transfer of the beta(2)-adrenergic receptor improves function of the transplanted rat heart." October 21, 1997.

Skiba, N, Bae, H, Ford, C, Daaka, Y, Reuvenv, E, Shekter, L, Biesen, TV, Yang, C-S, Lambright, D, Sondek, J, Sigler, P, Miller, R, Jan, L, Lefkowitz, R, and Hamm, H. "Molecular basis for gβγ-effector interaction: Structural correlation with ga binding site." 1997.

Milano, CA, Akhter, SA, Koch, WJ, Dolber, PC, Rindt, H, Grupp, IL, and Lefkowitz, RJ. "Functional effects of myocardial alpha-adrenergic receptor overexpression in transgenic mice." October 15, 1996.

BITTNER, HB, CHEN, EP, MILANO, CA, JENNINGS, RB, LEFKOWITZ, RJ, and VANTRIGT, P. "THE EFFECTS OF ISCHEMIA AND AGE ON MYOCARDIAL-FUNCTION IN HUMAN BETA-ADRENERGIC-RECEPTOR GENE OVEREXPRESSED HEARTS." October 15, 1995.

ROCKMAN, HA, HAMILTON, RA, RAHMAN, NI, MILANO, CA, LEFKOWITZ, RJ, and KOCH, WJ. "DAMPENED CARDIAC-FUNCTION IN-VIVO IN TRANSGENIC MICE OVEREXPRESSING GRK5, A G-PROTEIN-COUPLED RECEPTOR KINASE." October 15, 1995.

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