Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Wisler, JW, Xiao, K, Thomsen, ARB, and Lefkowitz, RJ. "Recent developments in biased agonism." Current Opinion in Cell Biology 27 (April 2014): 18-24. (Review) Full Text

Staus, DP, Wingler, LM, Strachan, RT, Rasmussen, SGF, Pardon, E, Ahn, S, Steyaert, J, Kobilka, BK, and Lefkowitz, RJ. "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies." Molecular Pharmacology 85.3 (March 2014): 472-481. Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "beta-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration." PLOS ONE 8.11 (November 8, 2013). Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "β-arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration." PLoS ONE 8.11 (November 8, 2013). Full Text

Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, X-P, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor." Acs Medicinal Chemistry Letters 4.10 (October 2013): 1005-1010. Full Text

Lefkowitz, RJ. "A brief history of G-protein coupled receptors (Nobel Lecture)." Angewandte Chemie (International Ed. in English) 52.25 (June 2013): 6366-6378. Full Text

Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (May 2013): 137-141. Full Text

Weiss, DR, Ahn, S, Sassano, MF, Kleist, A, Zhu, X, Strachan, R, Roth, BL, Lefkowitz, RJ, and Shoichet, BK. "Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor." Acs Chemical Biology 8.5 (May 2013): 1018-1026. Full Text

Hara, MR, Sachs, BD, Caron, MG, and Lefkowitz, RJ. "Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model." Cell Cycle (Georgetown, Tex.) 12.2 (January 2013): 219-224. Full Text

Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (2013): 137-141. Full Text

Pages

Maurice, JP, Hata, JA, Shah, AS, Wilson, KH, McDonald, PH, Lefkowitz, RJ, Glower, DD, and Koch, WJ. "Global myocardial overpression of beta(2)-adrenergic receptors via intracoronary adenovirus delivery enhances in vivo contractility." October 27, 1998.

Kypson, AP, Akhter, SA, Peppel, K, Hendrickson, SC, McDonald, P, Lilly, RE, Glower, DD, Lefkowitz, RJ, and Koch, WJ. "Adenoviral-mediated gene transfer of the beta(2)-adrenergic receptor improves function of the transplanted rat heart." October 21, 1997.

Skiba, N, Bae, H, Ford, C, Daaka, Y, Reuvenv, E, Shekter, L, Biesen, TV, Yang, C-S, Lambright, D, Sondek, J, Sigler, P, Miller, R, Jan, L, Lefkowitz, R, and Hamm, H. "Molecular basis for gβγ-effector interaction: Structural correlation with ga binding site." 1997.

Milano, CA, Akhter, SA, Koch, WJ, Dolber, PC, Rindt, H, Grupp, IL, and Lefkowitz, RJ. "Functional effects of myocardial alpha-adrenergic receptor overexpression in transgenic mice." October 15, 1996.

BITTNER, HB, CHEN, EP, MILANO, CA, JENNINGS, RB, LEFKOWITZ, RJ, and VANTRIGT, P. "THE EFFECTS OF ISCHEMIA AND AGE ON MYOCARDIAL-FUNCTION IN HUMAN BETA-ADRENERGIC-RECEPTOR GENE OVEREXPRESSED HEARTS." October 15, 1995.

ROCKMAN, HA, HAMILTON, RA, RAHMAN, NI, MILANO, CA, LEFKOWITZ, RJ, and KOCH, WJ. "DAMPENED CARDIAC-FUNCTION IN-VIVO IN TRANSGENIC MICE OVEREXPRESSING GRK5, A G-PROTEIN-COUPLED RECEPTOR KINASE." October 15, 1995.

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