M.D., Columbia University 1966
Lefkowitz, RJ. "A brief history of G-protein coupled receptors (Nobel Lecture)." Angew Chem Int Ed Engl 52.25 (June 17, 2013): 6366-6378. Full Text
Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (May 2, 2013): 137-141. Full Text
Hara, MR, Sachs, BD, Caron, MG, and Lefkowitz, RJ. "Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model." Cell Cycle 12.2 (January 15, 2013): 219-224. Full Text
Weiss, DR, Ahn, S, Sassano, MF, Kleist, A, Zhu, X, Strachan, R, Roth, BL, Lefkowitz, RJ, and Shoichet, BK. "Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor." ACS Chemical Biology 8.5 (2013): 1018-1026. Full Text
Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (2013): 137-141. Full Text
Lefkowitz, RJ. "Arrestins come of age: A personal historical perspective." Progress in Molecular Biology and Translational Science 118 (2013): 3-18. Full Text
Fereshteh, M, Ito, T, Kovacs, JJ, Zhao, C, Kwon, HY, Tornini, V, Konuma, T, Chen, M, Lefkowitz, RJ, and Reya, T. "β-Arrestin2 mediates the initiation and progression of myeloid leukemia." Proc Natl Acad Sci U S A 109.31 (July 31, 2012): 12532-12537. Full Text
Heitzler, D, Durand, G, Gallay, N, Rizk, A, Ahn, S, Kim, J, Violin, JD, Dupuy, L, Gauthier, C, Piketty, V, Crépieux, P, Poupon, A, Clément, F, Fages, F, Lefkowitz, RJ, and Reiter, E. "Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. (Published online)" Mol Syst Biol 8 (June 26, 2012): 590-. Full Text
Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)." Proceedings of the National Academy of Sciences of the United States of America 109.33 (2012): 13464--. Full Text
Reiter, E, Ahn, S, Shukla, AK, and Lefkowitz, RJ. "Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors." Annu Rev Pharmacol Toxicol 52 (2012): 179-197. (Review) Full Text
Iaccarino, G, Dolber, PC, Lefkowitz, RJ, and Koch, WJ. "beta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy - Regulation by beta- but not alpha(1)-adrenergic stimulation." January 1999. Full Text
Maurice, JP, Hata, JA, Shah, AS, Wilson, KH, McDonald, PH, Lefkowitz, RJ, Glower, DD, and Koch, WJ. "Global myocardial overpression of beta(2)-adrenergic receptors via intracoronary adenovirus delivery enhances in vivo contractility." October 27, 1998.
Kypson, AP, Akhter, SA, Peppel, K, Hendrickson, SC, McDonald, P, Lilly, RE, Glower, DD, Lefkowitz, RJ, and Koch, WJ. "Adenoviral-mediated gene transfer of the beta(2)-adrenergic receptor improves function of the transplanted rat heart." October 21, 1997.
Skiba, N, Bae, H, Ford, C, Daaka, Y, Reuvenv, E, Shekter, L, Biesen, TV, Yang, C-S, Lambright, D, Sondek, J, Sigler, P, Miller, R, Jan, L, Lefkowitz, R, and Hamm, H. "Molecular basis for gβγ-effector interaction: Structural correlation with ga binding site." 1997.
Zhang, J, Ferguson, SSG, Barak, LS, Aber, MJ, Giros, B, Lefkowitz, RJ, and Caron, MG. "Mini-Review - Molecular mechanisms of G protein-coupled receptor signaling: Role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization." 1997.
Akhter, SA, Milano, CA, Lefkowitz, RJ, and Koch, WJ. "Specific interactions between adrenergic receptors and receptor kinases in the hearts of hybrid transgenic mice." October 15, 1996.
Milano, CA, Akhter, SA, Koch, WJ, Dolber, PC, Rindt, H, Grupp, IL, and Lefkowitz, RJ. "Functional effects of myocardial alpha-adrenergic receptor overexpression in transgenic mice." October 15, 1996.
Pitcher, JA, Krueger, KM, Touhara, K, and Lefkowitz, RJ. "Recent insights into the mechanisms of agonist-specific G protein-coupled receptor desensitization and resensitization." 1996.
BITTNER, HB, CHEN, EP, MILANO, CA, JENNINGS, RB, LEFKOWITZ, RJ, and VANTRIGT, P. "THE EFFECTS OF ISCHEMIA AND AGE ON MYOCARDIAL-FUNCTION IN HUMAN BETA-ADRENERGIC-RECEPTOR GENE OVEREXPRESSED HEARTS." October 15, 1995.
ROCKMAN, HA, HAMILTON, RA, RAHMAN, NI, MILANO, CA, LEFKOWITZ, RJ, and KOCH, WJ. "DAMPENED CARDIAC-FUNCTION IN-VIVO IN TRANSGENIC MICE OVEREXPRESSING GRK5, A G-PROTEIN-COUPLED RECEPTOR KINASE." October 15, 1995.