Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Martin, NP, Whalen, EJ, Zamah, MA, Pierce, KL, and Lefkowitz, RJ. "PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching." Cell Signal 16.12 (December 2004): 1397-1403. Full Text

Usui, I, Imamura, T, Huang, J, Satoh, H, Shenoy, SK, Lefkowitz, RJ, Hupfeld, CJ, and Olefsky, JM. "beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1." Mol Cell Biol 24.20 (October 2004): 8929-8937. Full Text Open Access Copy

Ahn, S, Shenoy, SK, Wei, H, and Lefkowitz, RJ. "Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor." J Biol Chem 279.34 (August 20, 2004): 35518-35525. Full Text

Bohn, LM, Dykstra, LA, Lefkowitz, RJ, Caron, MG, and Barak, LS. "Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery." Mol Pharmacol 66.1 (July 2004): 106-112. Full Text

Witherow, DS, Garrison, TR, Miller, WE, and Lefkowitz, RJ. "beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha." Proc Natl Acad Sci U S A 101.23 (June 8, 2004): 8603-8607. Full Text

Freedman, NJ, and Lefkowitz, RJ. "Anti-β1-adrenergic receptor antibodies and heart failure: Causation, not just correlation." Journal of Clinical Investigation 113.10 (May 1, 2004): 1379-1382. (Review) Full Text

Freedman, NJ, and Lefkowitz, RJ. "Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation." J Clin Invest 113.10 (May 2004): 1379-1382. (Review) Full Text Open Access Copy

Lefkowitz, RJ, and Whalen, EJ. "beta-arrestins: traffic cops of cell signaling." Curr Opin Cell Biol 16.2 (April 2004): 162-168. (Review) Full Text

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