Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Xiao, K, Shenoy, SK, Nobles, K, and Lefkowitz, RJ. "Activation-dependent conformational changes in {beta}-arrestin 2." J Biol Chem 279.53 (December 31, 2004): 55744-55753. Full Text

Chen, W, Ren, X-R, Nelson, CD, Barak, LS, Chen, JK, Beachy, PA, de Sauvage, F, and Lefkowitz, RJ. "Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2." Science 306.5705 (December 24, 2004): 2257-2260. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Resonating to the music of ubiquitination." Nat Methods 1.3 (December 2004): 191-193. Full Text

Martin, NP, Whalen, EJ, Zamah, MA, Pierce, KL, and Lefkowitz, RJ. "PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching." Cell Signal 16.12 (December 2004): 1397-1403. Full Text

Usui, I, Imamura, T, Huang, J, Satoh, H, Shenoy, SK, Lefkowitz, RJ, Hupfeld, CJ, and Olefsky, JM. "beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1." Mol Cell Biol 24.20 (October 2004): 8929-8937. Full Text Open Access Copy

Ahn, S, Shenoy, SK, Wei, H, and Lefkowitz, RJ. "Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor." J Biol Chem 279.34 (August 20, 2004): 35518-35525. Full Text

Bohn, LM, Dykstra, LA, Lefkowitz, RJ, Caron, MG, and Barak, LS. "Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery." Mol Pharmacol 66.1 (July 2004): 106-112. Full Text

Witherow, DS, Garrison, TR, Miller, WE, and Lefkowitz, RJ. "beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha." Proc Natl Acad Sci U S A 101.23 (June 8, 2004): 8603-8607. Full Text

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