Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Lefkowitz, RJ, and Haber, E. "Physiological receptors as physicochemical entities." Circulation Research 32 (1973): Suppl 1:46-52-.

Lefkowitz, RJ. "Isolated beta adrenergic binding sites: a potential assay vehicle for catecholamines." Pharmacological Reviews 25.2 (1973): 259-268.

Lefkowitz, RJ, Haber, E, and O'Hara, D. "Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography." Proceedings of the National Academy of Sciences of the United States of America 69.10 (1972): 2828-2832.

Lefkowitz, RJ, and Levey, GS. "Norepinephrine: Dissociation of β-receptor binding from adenylate cyclase activation in solubilized myocardium." Life Sciences 11.16 PART 2 (1972): 821-828.

Lefkowitz, RJ, and Haber, E. "A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor." Proceedings of the National Academy of Sciences of the United States of America 68.8 (1971): 1773-1777.

Lefkowitz, RJ, Roth, J, and Pastan, I. "ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase." Annals of the New York Academy of Sciences 185 (1971): 195-209.

Lefkowitz, RJ, Roth, J, and Pastan, I. "Radioreceptor assay of adrenocorticotropic hormone: New approach to assay of polypeptide hormones in plasma." Science 170.3958 (1970): 633-635.

Lefkowitz, RJ, Roth, J, Pricer, W, and Pastan, I. "ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase." Proceedings of the National Academy of Sciences of the United States of America 65.3 (1970): 745-752.

Sibley, DR, and Lefkowitz, RJ. "Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation." Mol Neurobiol 1.1-2: 121-154. (Review)

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