Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Shenoy, SK, and Lefkowitz, RJ. "Receptor regulation: beta-arrestin moves up a notch." Nat Cell Biol 7.12 (December 2005): 1159-1161. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Angiotensin II-stimulated signaling through G proteins and beta-arrestin. (Published online)" Sci STKE 2005.311 (November 22, 2005): cm14-. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Seven-transmembrane receptor signaling through beta-arrestin. (Published online)" Sci STKE 2005.308 (November 1, 2005): cm10-. (Review) Full Text

Rajagopal, K, Lefkowitz, RJ, and Rockman, HA. "When 7 transmembrane receptors are not G protein-coupled receptors." J Clin Invest 115.11 (November 2005): 2971-2974. (Review) Full Text Open Access Copy

Beaulieu, J-M, Sotnikova, TD, Marion, S, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior." Cell 122.2 (July 29, 2005): 261-273. Full Text

Girnita, L, Shenoy, SK, Sehat, B, Vasilcanu, R, Girnita, A, Lefkowitz, RJ, and Larsson, O. "{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase." J Biol Chem 280.26 (July 1, 2005): 24412-24419. Full Text

Lefkowitz, RJ, and Shenoy, SK. "Transduction of receptor signals by beta-arrestins." Science 308.5721 (April 22, 2005): 512-517. (Review) Full Text

Hunton, DL, Barnes, WG, Kim, J, Ren, X-R, Violin, JD, Reiter, E, Milligan, G, Patel, DD, and Lefkowitz, RJ. "Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis." Mol Pharmacol 67.4 (April 2005): 1229-1236. Full Text

Barnes, WG, Reiter, E, Violin, JD, Ren, X-R, Milligan, G, and Lefkowitz, RJ. "beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation." J Biol Chem 280.9 (March 4, 2005): 8041-8050. Full Text

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