Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Lefkowitz, RJ. "Inspiring the next generation of physician-scientists." Journal of Clinical Investigation 125.8 (August 3, 2015): 2905-2907. Full Text

Soto, AG, Smith, TH, Chen, B, Bhattacharya, S, Cordova, IC, Kenakin, T, Vaidehi, N, and Trejo, J. "N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias." Proceedings of the National Academy of Sciences of the United States of America 112.27 (July 2015): E3600-E3608. Full Text

Tang, W, Strachan, RT, Lefkowitz, RJ, and Rockman, HA. "Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch." The Journal of biological chemistry 289.41 (October 2014): 28271-28283. Full Text

Shukla, AK, Westfield, GH, Xiao, K, Reis, RI, Huang, L-Y, Tripathi-Shukla, P, Qian, J, Li, S, Blanc, A, Oleskie, AN, Dosey, AM, Su, M, Liang, C-R, Gu, L-L, Shan, J-M, Chen, X, Hanna, R, Choi, M, Yao, XJ, Klink, BU, Kahsai, AW, Sidhu, SS, Koide, S, Penczek, PA, Kossiakoff, AA, Woods, VL, Kobilka, BK, Skiniotis, G, and Lefkowitz, RJ. "Visualization of arrestin recruitment by a G-protein-coupled receptor." Nature 512.7513 (August 2014): 218-222. Full Text Open Access Copy

Strachan, RT, Sun, J-P, Rominger, DH, Violin, JD, Ahn, S, Rojas Bie Thomsen, A, Zhu, X, Kleist, A, Costa, T, and Lefkowitz, RJ. "Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)." The Journal of biological chemistry 289.20 (May 2014): 14211-14224. Full Text

Wisler, JW, Xiao, K, Thomsen, ARB, and Lefkowitz, RJ. "Recent developments in biased agonism." Current Opinion in Cell Biology 27.1 (April 1, 2014): 18-24. (Review) Full Text

Staus, DP, Wingler, LM, Strachan, RT, Rasmussen, SGF, Pardon, E, Ahn, S, Steyaert, J, Kobilka, BK, and Lefkowitz, RJ. "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies." Mol Pharmacol 85.3 (March 2014): 472-481. Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "beta-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration." PLOS ONE 8.11 (November 8, 2013). Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "β-arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration." PLoS ONE 8.11 (November 8, 2013). Full Text

Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, XP, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 adrenergic receptor ligands using biosensor fragment screening of tagged wild-type receptor." ACS Medicinal Chemistry Letters 4.10 (October 10, 2013): 1005-1010. Full Text

Pages

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin dependent, G protein independent ERIK1/2 activation by the beta 2 adrenergic receptor." October 25, 2005.

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G-protein-independent ERK1/2 activation by the beta(2)-adrenergic receptor." October 25, 2005.

Rajagopal, K, Whalen, EJ, Violin, JD, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin 2-dependent positive inotropic and lusitropic responses to angiotensin II receptor stimulation in cardiomyocytes." October 25, 2005.

Gesty-Palmer, D, Reiter, E, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2." September 2005.

Xiao, KH, Shenoy, SK, Nobles, K, Oas, TG, and Lefkowitz, RJ. "Activation dependent conformational changes in beta-arrestin 2." January 2005.

Chakir, K, Zhang, SJ, Rhee, MH, Blumer, K, Lefkowitz, RJ, and Xiao, RP. "Use-dependent beta 2-adrenergic receptor-GI coupling requires RGS and beta-ARK/PKA-mediated receptor phosphorylation." October 26, 2004.

Walker, JKL, Lawson, BL, Schwartz, DA, and Lefkowitz, RJ. "beta-arrestin-2 regulation of lung eosinophilia in a mouse model of Th2-type airway inflammation." March 23, 2004.

Walker, JKL, Lawson, BL, Savov, JD, Schwartz, DA, and Lefkowitz, RJ. "[beta]-arrestin-2 regulates the development of allergic asthma in mice." March 17, 2003.

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