Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

M.D., Columbia University 1966

Strachan, RT, Sun, J-P, Rominger, DH, Violin, JD, Ahn, S, Rojas Bie Thomsen, A, Zhu, X, Kleist, A, Costa, T, and Lefkowitz, RJ. "Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)." The Journal of biological chemistry 289.20 (May 2014): 14211-14224. Full Text

Wisler, JW, Xiao, K, Thomsen, ARB, and Lefkowitz, RJ. "Recent developments in biased agonism." Current Opinion in Cell Biology 27.1 (April 1, 2014): 18-24. (Review) Full Text

Staus, DP, Wingler, LM, Strachan, RT, Rasmussen, SGF, Pardon, E, Ahn, S, Steyaert, J, Kobilka, BK, and Lefkowitz, RJ. "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies." Mol Pharmacol 85.3 (March 2014): 472-481. Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "beta-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration." PLOS ONE 8.11 (November 8, 2013). Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "β-arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration." PLoS ONE 8.11 (November 8, 2013). Full Text

Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, XP, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 adrenergic receptor ligands using biosensor fragment screening of tagged wild-type receptor." ACS Medicinal Chemistry Letters 4.10 (October 10, 2013): 1005-1010. Full Text

Lefkowitz, RJ. "A brief history of G-protein coupled receptors (Nobel Lecture)." Angew Chem Int Ed Engl 52.25 (June 17, 2013): 6366-6378. Full Text

Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (May 2, 2013): 137-141. Full Text

Weiss, DR, Ahn, S, Sassano, MF, Kleist, A, Zhu, X, Strachan, R, Roth, BL, Lefkowitz, RJ, and Shoichet, BK. "Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor." ACS Chemical Biology 8.5 (2013): 1018-1026. Full Text

Pages

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G-protein-independent ERK1/2 activation by the beta(2)-adrenergic receptor." October 25, 2005.

Rajagopal, K, Whalen, EJ, Violin, JD, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin 2-dependent positive inotropic and lusitropic responses to angiotensin II receptor stimulation in cardiomyocytes." October 25, 2005.

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin dependent, G protein independent ERIK1/2 activation by the beta 2 adrenergic receptor." October 25, 2005.

Gesty-Palmer, D, Reiter, E, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2." September 2005.

Xiao, KH, Shenoy, SK, Nobles, K, Oas, TG, and Lefkowitz, RJ. "Activation dependent conformational changes in beta-arrestin 2." January 2005.

Chakir, K, Zhang, SJ, Rhee, MH, Blumer, K, Lefkowitz, RJ, and Xiao, RP. "Use-dependent beta 2-adrenergic receptor-GI coupling requires RGS and beta-ARK/PKA-mediated receptor phosphorylation." October 26, 2004.

Walker, JKL, Lawson, BL, Schwartz, DA, and Lefkowitz, RJ. "beta-arrestin-2 regulation of lung eosinophilia in a mouse model of Th2-type airway inflammation." March 23, 2004.

Walker, JKL, Lawson, BL, Savov, JD, Schwartz, DA, and Lefkowitz, RJ. "[beta]-arrestin-2 regulates the development of allergic asthma in mice." March 17, 2003.

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