Faculty Profiles

Robert J. Lefkowitz
James B. Duke Professor of Medicine
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Lefkowitz, RJ. "Inspiring the next generation of physician-scientists." Journal of Clinical Investigation 125.8 (August 3, 2015): 2905-2907. Full Text

Soto, AG, Smith, TH, Chen, B, Bhattacharya, S, Cordova, IC, Kenakin, T, Vaidehi, N, and Trejo, J. "N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias." Proceedings of the National Academy of Sciences of the United States of America 112.27 (July 2015): E3600-E3608. Full Text

Tang, W, Strachan, RT, Lefkowitz, RJ, and Rockman, HA. "Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch." The Journal of biological chemistry 289.41 (October 2014): 28271-28283. Full Text

Shukla, AK, Westfield, GH, Xiao, K, Reis, RI, Huang, L-Y, Tripathi-Shukla, P, Qian, J, Li, S, Blanc, A, Oleskie, AN, Dosey, AM, Su, M, Liang, C-R, Gu, L-L, Shan, J-M, Chen, X, Hanna, R, Choi, M, Yao, XJ, Klink, BU, Kahsai, AW, Sidhu, SS, Koide, S, Penczek, PA, Kossiakoff, AA, Woods, VL, Kobilka, BK, Skiniotis, G, and Lefkowitz, RJ. "Visualization of arrestin recruitment by a G-protein-coupled receptor." Nature 512.7513 (August 2014): 218-222. Full Text Open Access Copy

Strachan, RT, Sun, J-P, Rominger, DH, Violin, JD, Ahn, S, Rojas Bie Thomsen, A, Zhu, X, Kleist, A, Costa, T, and Lefkowitz, RJ. "Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)." The Journal of biological chemistry 289.20 (May 2014): 14211-14224. Full Text

Wisler, JW, Xiao, K, Thomsen, ARB, and Lefkowitz, RJ. "Recent developments in biased agonism." Current Opinion in Cell Biology 27.1 (April 1, 2014): 18-24. (Review) Full Text

Staus, DP, Wingler, LM, Strachan, RT, Rasmussen, SGF, Pardon, E, Ahn, S, Steyaert, J, Kobilka, BK, and Lefkowitz, RJ. "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies." Mol Pharmacol 85.3 (March 2014): 472-481. Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "beta-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration." PLOS ONE 8.11 (November 8, 2013). Full Text

Simard, E, Kovacs, JJ, Miller, WE, Kim, J, Grandbois, M, and Lefkowitz, RJ. "β-arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration." PLoS ONE 8.11 (November 8, 2013). Full Text

Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, XP, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 adrenergic receptor ligands using biosensor fragment screening of tagged wild-type receptor." ACS Medicinal Chemistry Letters 4.10 (October 10, 2013): 1005-1010. Full Text

Pages

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G-protein-independent ERK1/2 activation by the beta(2)-adrenergic receptor." October 25, 2005.

Rajagopal, K, Whalen, EJ, Violin, JD, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin 2-dependent positive inotropic and lusitropic responses to angiotensin II receptor stimulation in cardiomyocytes." October 25, 2005.

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin dependent, G protein independent ERIK1/2 activation by the beta 2 adrenergic receptor." October 25, 2005.

Gesty-Palmer, D, Reiter, E, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2." September 2005.

Xiao, KH, Shenoy, SK, Nobles, K, Oas, TG, and Lefkowitz, RJ. "Activation dependent conformational changes in beta-arrestin 2." January 2005.

Chakir, K, Zhang, SJ, Rhee, MH, Blumer, K, Lefkowitz, RJ, and Xiao, RP. "Use-dependent beta 2-adrenergic receptor-GI coupling requires RGS and beta-ARK/PKA-mediated receptor phosphorylation." October 26, 2004.

Walker, JKL, Lawson, BL, Schwartz, DA, and Lefkowitz, RJ. "beta-arrestin-2 regulation of lung eosinophilia in a mouse model of Th2-type airway inflammation." March 23, 2004.

Walker, JKL, Lawson, BL, Savov, JD, Schwartz, DA, and Lefkowitz, RJ. "[beta]-arrestin-2 regulates the development of allergic asthma in mice." March 17, 2003.

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