Faculty Profiles

Pei Zhou
Professor of Chemistry
Office: 
270 Sands Building, Research Drive, Durham, NC 27710
Phone: 
(919) 668-6409
Fax: 
(919) 684-8885

Overview

Education:

Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Wang, T, Yu, Y, Liang, X, Luo, S, He, Z, Sun, Z, Jiang, Y, Omsland, A, Zhou, P, and Song, L. "Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells." Frontiers in Cellular and Infection Microbiology 8 (January 2018): 192-null. Full Text

Liu, Y, Rose, J, Huang, S, Hu, Y, Wu, Q, Wang, D, Li, C, Liu, M, Zhou, P, and Jiang, L. "A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases." Nature communications 8.1 (December 13, 2017): 2104-. Full Text

Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes." BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1862.11 (November 2017): 1424-1438. Full Text Open Access Copy

Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes." Biochimica et biophysica acta 1862.11 (November 2017): 1424-1438. (Review) Full Text Open Access Copy

Lemaître, N, Liang, X, Najeeb, J, Lee, C-J, Titecat, M, Leteurtre, E, Simonet, M, Toone, EJ, Zhou, P, and Sebbane, F. "Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC." Mbio 8.4 (July 25, 2017). Full Text Open Access Copy

Wu, Q, Fenton, BA, Wojtaszek, JL, and Zhou, P. "Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)." Chemical Communications (Cambridge, England) 53.61 (July 2017): 8541-8544. Full Text Open Access Copy

Zentella, R, Sui, N, Barnhill, B, Hsieh, W-P, Hu, J, Shabanowitz, J, Boyce, M, Olszewski, NE, Zhou, P, Hunt, DF, and Sun, T-P. "The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA." Nature chemical biology 13.5 (May 2017): 479-485. Full Text Open Access Copy

Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy

Cho, J, Lee, C-J, Zhao, J, Young, HE, and Zhou, P. "Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis." Nature microbiology 1.11 (August 15, 2016): 16154-. Full Text Open Access Copy

Wu, Q, Coggins, BE, and Zhou, P. "Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra." Nature communications 7 (July 27, 2016): 12281-. Full Text Open Access Copy

Pages

Coggins, BE, and Zhou, P. "CLEAN." New Developments in NMR. January 1, 2017. 169-219. Full Text

Coggins, BE, and Zhou, P. "Backprojection and Related Methods." New Developments in NMR. January 1, 2017. 119-168. Full Text

Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 2014. Full Text

Young, HE, Metzger, LE, Lee, JK, Stroud, RM, Zhou, P, and Raetz, CRH. "Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis." April 2012.

Zeng, D, Zhou, P, and Raetz, CRH. "Characterization of E. coli mutants resistant to LpxC inhibitors." April 2012.

Lee, C-J, Liang, X, Park, E, Zeng, D, Swanson, S, Chen, X, Nicholas, RA, Raetz, CRH, Toone, EJ, and Zhou, P. "Structure-activity relationships of diacetylene-based LpxC inhibitors." April 2012.

Greenleaf, AL, Phatnani, HP, Li, M, and Zhou, P. "Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2." March 6, 2006.