Post Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001
Ph.D., Harvard University 1998
Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes. (Accepted)" Biochimica et biophysica acta 1862.11 (November 2017): 1424-1438. (Review) Full Text Open Access Copy
Lemaître, N, Liang, X, Najeeb, J, Lee, C-J, Titecat, M, Leteurtre, E, Simonet, M, Toone, EJ, Zhou, P, and Sebbane, F. "Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC." mBio 8.4 (July 25, 2017). Full Text
Wu, Q, Fenton, BA, Wojtaszek, JL, and Zhou, P. "Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)." Chemical communications (Cambridge, England) 53.61 (July 14, 2017): 8541-8544. Full Text
Zentella, R, Sui, N, Barnhill, B, Hsieh, W-P, Hu, J, Shabanowitz, J, Boyce, M, Olszewski, NE, Zhou, P, Hunt, DF, and Sun, T-P. "The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA." Nature chemical biology 13.5 (May 2017): 479-485. Full Text
Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy
Cho, J, Lee, C-J, Zhao, J, Young, HE, and Zhou, P. "Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis." Nature microbiology 1.11 (August 15, 2016): 16154-. Full Text Open Access Copy
Wu, Q, Coggins, BE, and Zhou, P. "Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra." Nature communications 7 (July 27, 2016): 12281-. Full Text Open Access Copy
Liang, X, Gopalaswamy, R, Navas, F, Toone, EJ, and Zhou, P. "A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058." The Journal of organic chemistry 81.10 (May 2016): 4393-4398. Full Text Open Access Copy
Young, HE, Zhao, J, Barker, JR, Guan, Z, Valdivia, RH, and Zhou, P. "Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis." mBio 7.2 (March 22, 2016): e00090-. Full Text Open Access Copy
Lee, C-J, Liang, X, Wu, Q, Najeeb, J, Zhao, J, Gopalaswamy, R, Titecat, M, Sebbane, F, Lemaitre, N, Toone, EJ, and Zhou, P. "Drug design from the cryptic inhibitor envelope." Nature communications 7 (February 25, 2016): 10638-. Full Text Open Access Copy
Zhou, P, Zhang, F, and Pan, S. "A multi-frequency optoelectronic oscillator based on a single phase-modulator." August 10, 2015.
Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 28, 2014.
Liu, J, Fan, S, Lee, C-J, Greenleaf, AL, and Zhou, P. "Specific interaction of the TCERG1 FF4-6 tandem repeat domains with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the CTD." April 2013.
Masoudi, A, Pemble, CW, Raetz, CRH, and Zhou, P. "Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A." April 2013.
Lee, C-J, Liang, X, Park, E, Zeng, D, Swanson, S, Chen, X, Nicholas, RA, Raetz, CRH, Toone, EJ, and Zhou, P. "Structure-activity relationships of diacetylene-based LpxC inhibitors." April 2012.
Young, HE, Metzger, LE, Lee, JK, Stroud, RM, Zhou, P, and Raetz, CRH. "Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis." April 2012.
Zeng, D, Zhou, P, and Raetz, CRH. "Characterization of E. coli mutants resistant to LpxC inhibitors." April 2012.
Greenleaf, AL, Phatnani, HP, Li, M, and Zhou, P. "Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2." March 6, 2006.
McClerren, A, Rudolph, J, Zhou, P, and Raetz, CRH. "Mechanistic studies of the deacetylase LpxC, a novel target for drug design in gram-negative bacteria." May 14, 2004.