Faculty Profiles

Pei Zhou
Professor of Chemistry
Office: 
270 Sands Building, Research Drive, Durham, NC 27710
Phone: 
(919) 668-6409
Fax: 
(919) 684-8885

Overview

Education:

Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Barb, AW, Leavy, TM, Robins, LI, Guan, Z, Six, DA, Zhou, P, Hangauer, MJ, Bertozzi, CR, and Raetz, C. "Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q)." Biochemistry 48.32 (2009): 7776--. Full Text

Coggins, BE, and Zhou, P. "High resolution 4-D spectroscopy with sparse concentric shell sampling and FFT-CLEAN." J Biomol NMR 42.4 (December 2008): 225-239. Full Text

Barb, AW, and Zhou, P. "Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis." Curr Pharm Biotechnol 9.1 (February 2008): 9-15. (Review)

Zeng, JM, Tripathy, C, Zhou, P, and Donald, BR. "A HAUSDORFF-BASED NOE ASSIGNMENT ALGORITHM USING PROTEIN BACKBONE DETERMINED FROM RESIDUAL DIPOLAR COUPLINGS AND ROTAMER PATTERNS." Comput Syst Bioinformatics Conf 2008 (2008): 169-181.

Zeng, J, Tripathy, C, Zhou, P, and Donald, BR. "A Hausdorff-based NOE assignment algorithm using protein backbone determined from residual dipolar couplings and rotamer patterns." Comput Syst Bioinformatics Conf 7 (2008): 169-181.

Barb, AW, Jiang, L, Raetz, CRH, and Zhou, P. "Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding." Proc Natl Acad Sci U S A 104.47 (November 20, 2007): 18433-18438. Full Text

Pai, M-T, Tzeng, S-R, Kovacs, JJ, Keaton, MA, Li, SS-C, Yao, T-P, and Zhou, P. "Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin." J Mol Biol 370.2 (July 6, 2007): 290-302. Full Text

Lemieux, GA, Blumenkron, F, Yeung, N, Zhou, P, Williams, J, Grammer, AC, Petrovich, R, Lipsky, PE, Moss, ML, and Werb, Z. "The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10." The Journal of Biological Chemistry 282.20 (May 2007): 14836-14844. Full Text

Barb, AW, McClerren, AL, Snehelatha, K, Reynolds, CM, Zhou, P, and Raetz, CRH. "Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli." Biochemistry 46.12 (March 27, 2007): 3793-3802. Full Text

Bomar, MG, Pai, M-T, Tzeng, S-R, Li, SS-C, and Zhou, P. "Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta." EMBO Rep 8.3 (March 2007): 247-251. Full Text

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