Faculty Profiles

Pei Zhou
Professor of Biochemistry
Office: 
270 Sands Building, Research Drive, Durham, NC 27710
Phone: 
(919) 668-6409
Fax: 
(919) 684-8885

Overview

Education:

Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Masoudi, A, Raetz, CRH, Zhou, P, and Pemble IV, CW. "Chasing acyl carrier protein through a catalytic cycle of lipid A production." Nature 505.7483 (January 1, 2014): 422-426. Full Text

Lee, C-J, Liang, X, Gopalaswamy, R, Najeeb, J, Ark, ED, Toone, EJ, and Zhou, P. "Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC." ACS CHEMICAL BIOLOGY 9.1 (January 2014): 237-246. Full Text

Young, HE, Donohue, MP, Smirnova, TI, Smirnov, AI, and Zhou, P. "The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis." J Biol Chem 288.38 (September 20, 2013): 26987-27001. Full Text

Liang, X, Lee, C-J, Zhao, J, Toone, EJ, and Zhou, P. "Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors." J Med Chem 56.17 (September 12, 2013): 6954-6966. Full Text

Chung, BC, Zhao, J, Gillespie, RA, Kwon, D-Y, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis." Science 341.6149 (August 30, 2013): 1012-1016. Full Text

Feng, Y, Theis, T, Liang, X, Wang, Q, Zhou, P, and Warren, WS. "Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging." J Am Chem Soc 135.26 (July 3, 2013): 9632-9635. Full Text

Emptage, RP, Pemble, CW, York, JD, Raetz, CRH, and Zhou, P. "Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis." Biochemistry 52.13 (April 2, 2013): 2280-2290. Full Text

Zeng, D, Zhao, J, Chung, HS, Guan, Z, Raetz, CRH, and Zhou, P. "Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis." J Biol Chem 288.8 (February 22, 2013): 5475-5486. Full Text

Zeng, J, Zhou, P, and Donald, BR. "HASH: a program to accurately predict protein Hα shifts from neighboring backbone shifts." J Biomol NMR 55.1 (January 2013): 105-118. Full Text

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