Faculty Profiles

Pei Zhou
Professor of Chemistry
Office: 
270 Sands Building, Research Drive, Durham, NC 27710
Phone: 
(919) 668-6409
Fax: 
(919) 684-8885

Overview

Education:

Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Masoudi, A, Raetz, CRH, Zhou, P, and Pemble, CW. "Chasing acyl carrier protein through a catalytic cycle of lipid A production." Nature 505.7483 (January 2014): 422-426. Full Text

Masoudi, A, Raetz, CRH, Zhou, P, and Pemble IV, CW. "Chasing acyl carrier protein through a catalytic cycle of lipid A production." Nature 505.7483 (January 1, 2014): 422-426. Full Text

Lee, C-J, Liang, X, Gopalaswamy, R, Najeeb, J, Ark, ED, Toone, EJ, and Zhou, P. "Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC." ACS CHEMICAL BIOLOGY 9.1 (January 2014): 237-246. Full Text

Young, HE, Donohue, MP, Smirnova, TI, Smirnov, AI, and Zhou, P. "The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis." The Journal of Biological Chemistry 288.38 (September 2013): 26987-27001. Full Text

Liang, X, Lee, C-J, Zhao, J, Toone, EJ, and Zhou, P. "Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors." Journal of Medicinal Chemistry 56.17 (September 2013): 6954-6966. Full Text

Chung, BC, Zhao, J, Gillespie, RA, Kwon, D-Y, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis." Science (New York, N.Y.) 341.6149 (August 2013): 1012-1016. Full Text

Feng, Y, Theis, T, Liang, X, Wang, Q, Zhou, P, and Warren, WS. "Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging." Journal of the American Chemical Society 135.26 (July 2013): 9632-9635. Full Text

Emptage, RP, Pemble, CW, York, JD, Raetz, CRH, and Zhou, P. "Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis." Biochemistry 52.13 (April 2013): 2280-2290. Full Text

Zeng, D, Zhao, J, Chung, HS, Guan, Z, Raetz, CRH, and Zhou, P. "Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis." The Journal of Biological Chemistry 288.8 (February 2013): 5475-5486. Full Text

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