Post Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001
Ph.D., Harvard University 1998
Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes." Biochimica et biophysica acta (December 8, 2016). (Review) Full Text Open Access Copy
Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy
Cho, J, Lee, C-J, Zhao, J, Young, HE, and Zhou, P. "Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis." Nature microbiology 1.11 (August 15, 2016): 16154-. Full Text Open Access Copy
Wu, Q, Coggins, BE, and Zhou, P. "Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra." Nature communications 7 (July 27, 2016): 12281-. Full Text Open Access Copy
Liang, X, Gopalaswamy, R, Navas, F, Toone, EJ, and Zhou, P. "A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058." The Journal of organic chemistry 81.10 (May 2016): 4393-4398. Full Text Open Access Copy
Young, HE, Zhao, J, Barker, JR, Guan, Z, Valdivia, RH, and Zhou, P. "Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis." mBio 7.2 (March 22, 2016): e00090-. Full Text Open Access Copy
Lee, C-J, Liang, X, Wu, Q, Najeeb, J, Zhao, J, Gopalaswamy, R, Titecat, M, Sebbane, F, Lemaitre, N, Toone, EJ, and Zhou, P. "Drug design from the cryptic inhibitor envelope." Nature communications 7 (February 25, 2016): 10638-. Full Text Open Access Copy
Gong, C, Huang, M, Zhou, P, Sun, Z, Fan, L, Lin, J, and Wu, J. "Mesoporous Co0.85Se nanosheets supported on Ni foam as a positive electrode material for asymmetric supercapacitor." Applied Surface Science 362 (January 2016): 469-476. Full Text
Deis, LN, Wu, Q, Wang, Y, Qi, Y, Daniels, KG, Zhou, P, and Oas, TG. "Suppression of conformational heterogeneity at a protein-protein interface." Proceedings of the National Academy of Sciences of the United States of America 112.29 (July 8, 2015): 9028-9033. Full Text Open Access Copy
Martin, JW, Zhou, P, and Donald, BR. "Systematic solution to homo-oligomeric structures determined by NMR." Proteins 83.4 (April 2015): 651-661. Full Text
Zhou, P, Zhang, F, and Pan, S. "A multi-frequency optoelectronic oscillator based on a single phase-modulator." August 10, 2015.
Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 28, 2014.
Liu, J, Fan, S, Lee, C-J, Greenleaf, AL, and Zhou, P. "Specific interaction of the TCERG1 FF4-6 tandem repeat domains with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the CTD." April 2013.
Masoudi, A, Pemble, CW, Raetz, CRH, and Zhou, P. "Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A." April 2013.
Lee, C-J, Liang, X, Park, E, Zeng, D, Swanson, S, Chen, X, Nicholas, RA, Raetz, CRH, Toone, EJ, and Zhou, P. "Structure-activity relationships of diacetylene-based LpxC inhibitors." April 2012.
Young, HE, Metzger, LE, Lee, JK, Stroud, RM, Zhou, P, and Raetz, CRH. "Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis." April 2012.
Zeng, D, Zhou, P, and Raetz, CRH. "Characterization of E. coli mutants resistant to LpxC inhibitors." April 2012.
Greenleaf, AL, Phatnani, HP, Li, M, and Zhou, P. "Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2." March 6, 2006.
McClerren, A, Rudolph, J, Zhou, P, and Raetz, CRH. "Mechanistic studies of the deacetylase LpxC, a novel target for drug design in gram-negative bacteria." May 14, 2004.