Faculty Profiles

Pei Zhou
Professor of Biochemistry
270 Sands Building, Research Drive, Durham, NC 27710
(919) 668-6409
(919) 684-8885



Post Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes. (Accepted)" Biochimica et biophysica acta 1862.11 (November 2017): 1424-1438. (Review) Full Text Open Access Copy

Lemaître, N, Liang, X, Najeeb, J, Lee, C-J, Titecat, M, Leteurtre, E, Simonet, M, Toone, EJ, Zhou, P, and Sebbane, F. "Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC." mBio 8.4 (July 25, 2017). Full Text

Wu, Q, Fenton, BA, Wojtaszek, JL, and Zhou, P. "Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)." Chemical communications (Cambridge, England) 53.61 (July 14, 2017): 8541-8544. Full Text

Zentella, R, Sui, N, Barnhill, B, Hsieh, W-P, Hu, J, Shabanowitz, J, Boyce, M, Olszewski, NE, Zhou, P, Hunt, DF, and Sun, T-P. "The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA." Nature chemical biology 13.5 (May 2017): 479-485. Full Text

Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy

Cho, J, Lee, C-J, Zhao, J, Young, HE, and Zhou, P. "Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis." Nature microbiology 1.11 (August 15, 2016): 16154-. Full Text Open Access Copy

Wu, Q, Coggins, BE, and Zhou, P. "Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra." Nature communications 7 (July 27, 2016): 12281-. Full Text Open Access Copy

Liang, X, Gopalaswamy, R, Navas, F, Toone, EJ, and Zhou, P. "A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058." The Journal of organic chemistry 81.10 (May 2016): 4393-4398. Full Text Open Access Copy

Young, HE, Zhao, J, Barker, JR, Guan, Z, Valdivia, RH, and Zhou, P. "Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis." mBio 7.2 (March 22, 2016): e00090-. Full Text Open Access Copy

Lee, C-J, Liang, X, Wu, Q, Najeeb, J, Zhao, J, Gopalaswamy, R, Titecat, M, Sebbane, F, Lemaitre, N, Toone, EJ, and Zhou, P. "Drug design from the cryptic inhibitor envelope." Nature communications 7 (February 25, 2016): 10638-. Full Text Open Access Copy


Coggins, BE, and Zhou, P. "CLEAN." New Developments in NMR. January 1, 2017. 169-219. Full Text

Coggins, BE, and Zhou, P. "Backprojection and Related Methods." New Developments in NMR. January 1, 2017. 119-168. Full Text

Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 28, 2014.

Lee, C-J, Liang, X, Park, E, Zeng, D, Swanson, S, Chen, X, Nicholas, RA, Raetz, CRH, Toone, EJ, and Zhou, P. "Structure-activity relationships of diacetylene-based LpxC inhibitors." April 2012.

Young, HE, Metzger, LE, Lee, JK, Stroud, RM, Zhou, P, and Raetz, CRH. "Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis." April 2012.

Zeng, D, Zhou, P, and Raetz, CRH. "Characterization of E. coli mutants resistant to LpxC inhibitors." April 2012.

Greenleaf, AL, Phatnani, HP, Li, M, and Zhou, P. "Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2." March 6, 2006.