Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Smith, J, and Modrich, P. "Removal of polymerase-produced mutant sequences from PCR products." Proc Natl Acad Sci U S A 94.13 (June 24, 1997): 6847-6850.

Modrich, P. "Strand-specific mismatch repair in mammalian cells." Journal of Biological Chemistry 272.40 (1997): 24727-24730. Full Text

Drummond, JT, Genschel, J, Wolf, E, and Modrich, P. "DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base-base mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 94.19 (1997): 10144-10149. Full Text

Allen, DJ, Makhov, A, Grilley, M, Taylor, J, Thresher, R, Modrich, P, and Griffith, JD. "MutS mediates heteroduplex loop formation by a translocation mechanism." EMBO Journal 16.14 (1997): 4467-4476. Full Text

Allison, DP, Kerper, PS, Doktycz, MJ, Thundat, T, Modrich, P, Larimer, FW, Johnson, DK, Hoyt, PR, Mucenski, ML, and Warmack, RJ. "Mapping individual cosmid DNAs by direct AFM imaging." Genomics 41.3 (1997): 379-384. Full Text

Longley, MJ, Pierce, AJ, and Modrich, P. "DNA polymerase δ is required for human mismatch repair in vitro." Journal of Biological Chemistry 272.16 (1997): 10917-10921. Full Text

Mu, D, Tursun, M, Duckett, DR, Drummond, JT, Modrich, P, and Sancar, A. "Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems." Molecular and Cellular Biology 17.2 (1997): 760-769.

Drummond, J, Duckett, D, Genschel, J, Lonyley, M, Pierce, A, Litlman, S, Li, G-M, and Modrich, P. "MutSα MutSβ, MutLα and DNA polymerase ôin human mismatch repair." FASEB Journal 11.9 (1997): A1012-.

Drummond, JT, Anthoney, A, Brown, R, and Modrich, P. "Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line." J Biol Chem 271.33 (August 16, 1996): 19645-19648.

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