Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Veigl, ML, Kasturi, L, Olechnowicz, J, Ma, AH, Lutterbaugh, JD, Periyasamy, S, Li, GM, Drummond, J, Modrich, PL, Sedwick, WD, and Markowitz, SD. "Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers." Proc Natl Acad Sci U S A 95.15 (July 21, 1998): 8698-8702.

Lee, SE, Johnson, SP, Hale, LP, Li, J, Bullock, N, Fuchs, H, Friedman, A, McLendon, R, Bigner, DD, Modrich, P, and Friedman, HS. "Analysis of DNA mismatch repair proteins in human medulloblastoma." Clin Cancer Res 4.6 (June 1998): 1415-1419.

Nicolaides, NC, Littman, SJ, Modrich, P, Kinzler, KW, and Vogelstein, B. "A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype." Molecular and Cellular Biology 18.3 (1998): 1635-1641.

Hanley, ML, Elion, GB, Colvin, OM, Modrich, PL, Keir, S, Adams, DJ, Bigner, DD, and Friedman, HS. "Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors." Cancer Chemother Pharmacol 42.6 (1998): 479-482.

Genschel, J, Littman, SJ, Drummond, JT, and Modrich, P. "Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα." Journal of Biological Chemistry 273.31 (1998): 19895-19901. Full Text

Yamaguchi, M, Dao, V, and Modrich, P. "MutS and MutL activate DNA helicase II in a mismatch-dependent manner." Journal of Biological Chemistry 273.15 (1998): 9197-9201. Full Text

Eshleman, JR, Donover, PS, Littman, SJ, Swinler, SE, Li, G-M, Lutterbaugh, JD, Willson, JKV, Modrich, P, Sedwick, WD, Markowitz, SD, and Veigl, ML. "Increased transversions in a novel mutator colon cancer cell line." Oncogene 16.9 (1998): 1125-1130.

Friedman, HS, Johnson, SP, Dong, Q, Schold, SC, Rasheed, BK, Bigner, SH, Ali-Osman, F, Dolan, E, Colvin, OM, Houghton, P, Germain, G, Drummond, JT, Keir, S, Marcelli, S, Bigner, DD, and Modrich, P. "Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft." Cancer Res 57.14 (July 15, 1997): 2933-2936.