Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Spampinato, C, and Modrich, P. "The MutL ATPase is required for mismatch repair." Journal of Biological Chemistry 275.13 (2000): 9863-9869. Full Text

Ma, A-H, Xia, L, Littman, SJ, Swinler, S, Lader, G, Polinkovsky, A, Olechnowicz, J, Kasturi, L, Lutterbaugh, J, Modrich, P, Veigl, ML, Markowitz, SD, and Sedwick, WD. "Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability." Oncogene 19.18 (2000): 2249-2256.

Friedman, HS, Pegg, AE, Johnson, SP, Loktionova, NA, Dolan, ME, Modrich, P, Moschel, RC, Struck, R, Brent, TP, Ludeman, S, Bullock, N, Kilborn, C, Keir, S, Dong, Q, Bigner, DD, and Colvin, OM. "Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase." Cancer Chemother Pharmacol 43.1 (1999): 80-85. Full Text

Dong, Q, Johnson, SP, Colvin, OM, Bullock, N, Kilborn, C, Runyon, G, Sullivan, DM, Easton, J, Bigner, DD, Nahta, R, Marks, J, Modrich, P, and Friedman, HS. "Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)." Cancer Chemother Pharmacol 43.1 (1999): 73-79. Full Text

Blackwell, LJ, Martik, D, Bjornson, KP, Bjornson, ES, and Modrich, P. "Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism." Journal of Biological Chemistry 273.48 (1999): 32055-32062. Full Text

Blackwell, LJ, Bjornson, KP, and Modrich, P. "DNA-dependent activation of the hMutSα ATPase." Journal of Biological Chemistry 273.48 (1999): 32049-32054. Full Text

Wright, DJ, Jack, WE, and Modrich, P. "The kinetic mechanism of EcoRI endonuclease." Journal of Biological Chemistry 274.45 (1999): 31896-31902. Full Text

Duckett, DR, Bronstein, SM, Taya, Y, and Modrich, P. "hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage." Proceedings of the National Academy of Sciences of the United States of America 96.22 (1999): 12384-12388. Full Text

Friedman, HS, McLendon, RE, Kerby, T, Dugan, M, Bigner, SH, Henry, AJ, Ashley, DM, Krischer, J, Lovell, S, Rasheed, K, Marchev, F, Seman, AJ, Cokgor, I, Rich, J, Stewart, E, Colvin, OM, Provenzale, JM, Bigner, DD, Haglund, MM, Friedman, AH, and Modrich, PL. "DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma." J Clin Oncol 16.12 (December 1998): 3851-3857. Full Text

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