Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Bjornson, KP, and Modrich, P. "Differential and simultaneous adenosine di- and triphosphate binding by MutS." J Biol Chem 278.20 (May 16, 2003): 18557-18562. Full Text

Bacolod, MD, Johnson, SP, Ali-Osman, F, Modrich, P, Bullock, NS, Colvin, OM, Bigner, DD, and Friedman, HS. "Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma." Mol Cancer Ther 1.9 (July 2002): 727-736.

Genschel, J, Bazemore, LR, and Modrich, P. "Human exonuclease I is required for 5' and 3' mismatch repair." J Biol Chem 277.15 (April 12, 2002): 13302-13311. Full Text

Chen, S, Bigner, SH, and Modrich, P. "High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6." Proceedings of the National Academy of Sciences of the United States of America 98.24 (2001): 13802-13807. Full Text

Blackwell, LJ, Wang, S, and Modrich, P. "DNA Chain Length Dependence of Formation and Dynamics of hMutSα·hMutLα·Heteroduplex Complexes." Journal of Biological Chemistry 276.35 (2001): 33233-33240. Full Text

Blackwell, LJ, Bjornson, KP, Allen, DJ, and Modrich, P. "Distinct MutS DNA-binding Modes That Are Differentially Modulated by ATP Binding and Hydrolysis." Journal of Biological Chemistry 276.36 (2001): 34339-34347. Full Text

Burdett, V, Baitinger, C, Viswanathan, M, Lovett, ST, and Modrich, P. "In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 98.12 (2001): 6765-6770. Full Text

Viswanathan, M, Burdett, V, Baitinger, C, Modrich, P, and Lovett, ST. "Redundant Exonuclease Involvement in Escherichia coli Methyl-directed Mismatch Repair." Journal of Biological Chemistry 276.33 (2001): 31053-31058. Full Text

Spampinato, C, and Modrich, P. "The MutL ATPase is required for mismatch repair." Journal of Biological Chemistry 275.13 (2000): 9863-9869. Full Text

Ma, A-H, Xia, L, Littman, SJ, Swinler, S, Lader, G, Polinkovsky, A, Olechnowicz, J, Kasturi, L, Lutterbaugh, J, Modrich, P, Veigl, ML, Markowitz, SD, and Sedwick, WD. "Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability." Oncogene 19.18 (2000): 2249-2256.

Pages