Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Constantin, N, Dzantiev, L, Kadyrov, FA, and Modrich, P. "Human mismatch repair: Reconstitution of a nick-directed bidirectional reaction." Journal of Biological Chemistry 280.48 (2005): 39752-39761. Full Text

Modrich, P. "Early thinking on the nature of mismatch repair." DNA Repair 4.1 (2005): 103-131. Full Text

Bacolod, MD, Johnson, SP, Pegg, AE, Dolan, ME, Moschel, RC, Bullock, NS, Fang, Q, Colvin, OM, Modrich, P, Bigner, DD, and Friedman, HS. "Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations." Mol Cancer Ther 3.9 (September 2004): 1127-1135.

Martik, D, Baitinger, C, and Modrich, P. "Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites." J Biol Chem 279.27 (July 2, 2004): 28402-28410. Full Text

Dzantiev, L, Constantin, N, Genschel, J, Iyer, RR, Burgers, PM, and Modrich, P. "A defined human system that supports bidirectional mismatch-provoked excision." Mol Cell 15.1 (July 2, 2004): 31-41. Full Text

Vilenchik, M, Solit, D, Basso, A, Huezo, H, Lucas, B, He, H, Rosen, N, Spampinato, C, Modrich, P, and Chiosis, G. "Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90." Chem Biol 11.6 (June 2004): 787-797. Full Text

Yang, Q, Zhang, R, Wang, XW, Linke, SP, Sengupta, S, Hickson, ID, Pedrazzi, G, Perrera, C, Stagljar, I, Littman, SJ, Modrich, P, and Harris, CC. "The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase." Oncogene 23.21 (May 6, 2004): 3749-3756. Full Text

Genschel, J, and Modrich, P. "Mechanism of 5'-directed excision in human mismatch repair." Mol Cell 12.5 (November 2003): 1077-1086.

Bjornson, KP, Blackwell, LJ, Sage, H, Baitinger, C, Allen, D, and Modrich, P. "Assembly and molecular activities of the MutS tetramer." J Biol Chem 278.36 (September 5, 2003): 34667-34673. Full Text

Pages