Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Iyer, RR, Pluciennik, A, Burdett, V, and Modrich, PL. "DNA mismatch repair: functions and mechanisms." Chem Rev 106.2 (February 2006): 302-323. (Review) Full Text

Modrich, P. "Mechanisms in eukaryotic mismatch repair." Journal of Biological Chemistry 281.41 (2006): 30305-30309. Full Text

Kadyrov, FA, Dzantiev, L, Constantin, N, and Modrich, P. "Endonucleolytic Function of MutLα in Human Mismatch Repair." Cell 126.2 (2006): 297-308. Full Text

Baker, D, Church, G, Collins, J, Endy, D, Jacobson, J, Keasling, J, Modrich, P, Smolke, C, and Weiss, R. "Engineering life: Building a FAB for biology." Scientific American 294.6 (2006): 44-51.

York, SJ, and Modrich, P. "Mismatch repair-dependent iterative excision at irreparable O 6-methylguanine lesions in human nuclear extracts." Journal of Biological Chemistry 281.32 (2006): 22674-22683. Full Text

Saro, FJLD, Marinus, MG, Modrich, P, and O'Donnell, M. "The β sliding clamp binds to multiple sites within MutL and MutS." Journal of Biological Chemistry 281.20 (2006): 14340-14349. Full Text

Genschel, J, and Modrich, P. "Analysis of the Excision Step in Human DNA Mismatch Repair." Methods in Enzymology 408 (2006): 273-284. Full Text

Cheng, CL, Johnson, SP, Keir, ST, Quinn, JA, Ali-Osman, F, Szabo, C, Li, H, Salzman, AL, Dolan, ME, Modrich, P, Bigner, DD, and Friedman, HS. "Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft." Mol Cancer Ther 4.9 (September 2005): 1364-1368. Full Text

Koshiji, M, To, KK-W, Hammer, S, Kumamoto, K, Harris, AL, Modrich, P, and Huang, LE. "HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression." Mol Cell 17.6 (March 18, 2005): 793-803. Full Text

Lu, A-L, Clark, S, and Modrich, P. "Methyl-directed repair of DNA base-pair mismatches in vitro. 1983." DNA Repair (Amst) 4.1 (January 2, 2005): 134-138. Full Text

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