Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Genschel, J, and Modrich, P. "Functions of MutLα, replication protein A (RPA), and HMGB1 in 5′-directed mismatch repair." Journal of Biological Chemistry 284.32 (2009): 21536-21544. Full Text

Kadyrov, FA, Genschel, J, Fang, Y, Penland, E, Edelmann, W, and Modrich, P. "A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 106.21 (2009): 8495-8500. Full Text

Maxwell, JA, Johnson, SP, McLendon, RE, Lister, DW, Horne, KS, Rasheed, A, Quinn, JA, Ali-Osman, F, Friedman, AH, Modrich, PL, Bigner, DD, and Friedman, HS. "Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma." Clin Cancer Res 14.15 (August 1, 2008): 4859-4868. Full Text

Iyer, RR, Pohlhaus, TJ, Chen, S, Hura, GL, Dzantiev, L, Beese, LS, and Modrich, P. "The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair." J Biol Chem 283.19 (May 9, 2008): 13310-13319. Full Text

Nimonkar, AV, Özsoy, AZ, Genschel, J, Modrich, P, and Kowalczykowski, SC. "Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair." Proceedings of the National Academy of Sciences of the United States of America 105.44 (2008): 16906-16911. Full Text

Sacho, EJ, Kadyrov, FA, Modrich, P, Kunkel, TA, and Erie, DA. "Direct Visualization of Asymmetric Adenine Nucleotide-Induced Conformational Changes in MutLα." Molecular Cell 29.1 (2008): 112-121. Full Text

Warren, JJ, Pohlhaus, TJ, Changela, A, Iyer, RR, Modrich, PL, and Beese, LS. "Structure of the human MutSalpha DNA lesion recognition complex." Mol Cell 26.4 (May 25, 2007): 579-592. Full Text

Kadyrov, FA, Holmes, SF, Arana, ME, Lukianova, OA, O'Donnell, M, Kunkel, TA, and Modrich, P. "Saccharomyces cerevisiae MutLα is a mismatch repair endonuclease." Journal of Biological Chemistry 282.51 (2007): 37181-37190. Full Text

Pluciennik, A, and Modrich, P. "Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 104.31 (2007): 12709-12713. Full Text

Chintagumpala, MM, Friedman, HS, Stewart, CF, Kepner, J, McLendon, RE, Modrich, PL, McCluggage, C, Burger, P, Holmes, E, Thompson, S, Rutka, J, Michalski, J, Woo, S, Blaney, SM, Kun, LE, Horowitz, ME, and Pediatric Oncology Group Study, . "A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group." J Neurooncol 77.2 (April 2006): 193-198. Full Text

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