Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Tseng, Q, Orans, J, Hast, MA, Iyer, RR, Changela, A, Modrich, PL, and Beese, LS. "Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ." Acta Crystallogr Sect F Struct Biol Cryst Commun 67.Pt 8 (August 1, 2011): 947-952. Full Text

Orans, J, McSweeney, EA, Iyer, RR, Hast, MA, Hellinga, HW, Modrich, P, and Beese, LS. "Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family." Cell 145.2 (April 15, 2011): 212-223. Full Text

Nimonkar, AV, Genschel, J, Kinoshita, E, Polaczek, P, Campbell, JL, Wyman, C, Modrich, P, and Kowalczykowski, SC. "BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair." Genes and Development 25.4 (2011): 350-362. Full Text

Iyer, RR, Pluciennik, A, Genschel, J, Tsai, M-S, Beese, LS, and Modrich, P. "MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta." J Biol Chem 285.15 (April 9, 2010): 11730-11739. Full Text

Liu, Y, Fang, Y, Shao, H, Lindsey-Boltz, L, Sancar, A, and Modrich, P. "Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway." J Biol Chem 285.8 (February 19, 2010): 5974-5982. Full Text

Pluciennik, A, Dzantiev, L, Iyer, RR, Constantin, N, Kadyrov, FA, and Modrich, P. "PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 107.37 (2010): 16066-16071. Full Text

Oers, JMMV, Roa, S, Werling, U, Liu, Y, Genschel, J, Jr, HH, Sellers, RS, Modrich, P, Scharff, MD, and Edelmann, W. "PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance." Proceedings of the National Academy of Sciences of the United States of America 107.30 (2010): 13384-13389. Full Text

Pillon, MC, Lorenowicz, JJ, Uckelmann, M, Klocko, AD, Mitchell, RR, Chung, YS, Modrich, P, Walker, GC, Simmons, LA, Friedhoff, P, and Guarné, A. "Structure of the Endonuclease Domain of MutL: Unlicensed to Cut." Molecular Cell 39.1 (2010): 145-151. Full Text

Zhao, J, Jain, A, Iyer, RR, Modrich, PL, and Vasquez, KM. "Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks." Nucleic Acids Res 37.13 (July 2009): 4420-4429. Full Text

Pluciennik, A, Burdett, V, Lukianova, O, O'Donnell, M, and Modrich, P. "Involvement of the β clamp in methyl-directed mismatch repair in vitro." Journal of Biological Chemistry 284.47 (2009): 32782-32791. Full Text

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