Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Medicine
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Modrich, P. "Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)." Angewandte Chemie International Edition 55.30 (July 18, 2016): 8490-8501. Full Text

Qiu, R, Sakato, M, Sacho, EJ, Wilkins, H, Zhang, X, Modrich, P, Hingorani, MM, Erie, DA, and Weninger, KR. "MutL traps MutS at a DNA mismatch." Proceedings of the National Academy of Sciences of the United States of America 112.35 (September 2015): 10914-10919. Full Text

Shao, H, Baitinger, C, Soderblom, EJ, Burdett, V, and Modrich, P. "Hydrolytic function of Exo1 in mammalian mismatch repair." Nucleic acids research 42.11 (June 2014): 7104-7112. Full Text

Lindsey-Boltz, LA, Kemp, MG, Reardon, JT, DeRocco, V, Iyer, RR, Modrich, P, and Sancar, A. "Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system." The Journal of biological chemistry 289.8 (February 2014): 5074-5082. Full Text

Lindsey-Boltz, LA, Kemp, MG, Reardon, JT, DeRocco, V, Iyer, RR, Modrich, P, and Sancar, A. "Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system." Journal of Biological Chemistry 289.8 (2014): 5074-5082. Full Text

Dowhan, W, Nikaido, H, Stubbe, J, Kozarich, JW, Wickner, WT, Russell, DW, Garrett, TA, Brozek, K, and Modrich, P. "Christian Raetz: scientist and friend extraordinaire." Annual review of biochemistry 82 (2013): 1-24. Full Text

Pluciennik, A, Burdett, V, Baitinger, C, Iyer, RR, Shi, K, and Modrich, P. "Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLa endonuclease activation." Proceedings of the National Academy of Sciences of the United States of America 110.30 (2013): 12277-12282. Full Text

Liu, Y, Kadyrov, FA, and Modrich, P. "PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro." DNA Repair (Amst) 10.11 (November 10, 2011): 1145-1153. Full Text

Tseng, Q, Orans, J, Hast, MA, Iyer, RR, Changela, A, Modrich, PL, and Beese, LS. "Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ." Acta Crystallogr Sect F Struct Biol Cryst Commun 67.Pt 8 (August 1, 2011): 947-952. Full Text

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