Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
Office: 
5330 French Family Science Cen, Durham, NC 27708
Phone: 
(919) 660-1670
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Hyslop, AG, Kellett, MA, Iovine, PM, and Therien, MJ. "Suzuki porphyrins: New synthons for the fabrication of porphyrin- containing supramolecular assemblies [6]." Journal of the American Chemical Society 120.48 (1998): 12676-12677. Full Text

Kumble, R, Palese, S, Lin, VS-Y, Therien, MJ, and Hochstrasser, RM. "Ultrafast dynamics of highly conjugated porphyrin arrays." Journal of the American Chemical Society 120.44 (1998): 11489-11498. Full Text

Karki, L, Vance, FW, Hupp, JT, LeCours, SM, and Therien, MJ. "Electronic stark effect studies of a porphyrin-based push-pull chromophore displaying a large first hyperpolarizability: State-specific contributions to β." Journal of the American Chemical Society 120.11 (1998): 2606-2611. Full Text

Chan, CC, Panneton, M, Taylor, AM, Therien, M, and Rodger, IW. "A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates." European journal of pharmacology 327.2-3 (May 1997): 221-225. Full Text

Riendeau, D, Percival, MD, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Falgueyret, JP, Ford-Hutchinson, AW, Gordon, R, Greig, G, Gresser, M, Guay, J, Kargman, S, Léger, S, Mancini, JA, O'Neill, G, Ouellet, M, Rodger, IW, Thérien, M, Wang, Z, Webb, JK, Wong, E, and Chan, CC. "Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor." British Journal of Pharmacology 121.1 (May 1997): 105-117. Full Text

Moore, KT, Horvath, IT, and Therien, MJ. "High-pressure NMR studies of (porphinato)iron-catalyzed isobutane oxidation utilizing dioxygen as the stoichiometric oxidant." Journal of the American Chemical Society 119.7 (1997): 1791-1792. Full Text

Thérien, M, Brideau, C, Chan, CC, Cromlish, WA, Gauthier, JY, Gordon, R, Greig, G, Kargman, S, Lau, CK, Leblanc, Y, Li, C-S, O'Neill, GP, Riendeau, D, Roy, P, Wang, Z, Xu, L, and Prasit, P. "Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors." Bioorganic & Medicinal Chemistry Letters 7.1 (January 1997): 47-52. Full Text

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