Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
5330 French Family Science Cen, Durham, NC 27708
(919) 660-1670
(919) 660-1605



NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Chan, CC, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Ford-Hutchinson, AW, Forrest, MJ, Gauthier, JY, Gordon, R, Gresser, M, Guay, J, Kargman, S, Kennedy, B, Leblanc, Y, Leger, S, Mancini, J, O'Neill, GP, Ouellet, M, Patrick, D, Percival, MD, Perrier, H, Prasit, P, and Rodger, I. "Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles." The Journal of Pharmacology and Experimental Therapeutics 290.2 (August 1999): 551-560.

Frenette, R, Hutchinson, JH, Léger, S, Thérien, M, Brideau, C, Chan, CC, Charleson, S, Ethier, D, Guay, J, Jones, TR, McAuliffe, M, Piechuta, H, Riendeau, D, Tagari, P, and Girard, Y. "Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors." Bioorganic & medicinal chemistry letters 9.16 (August 1999): 2391-2396. Full Text

Prasit, P, Wang, Z, Brideau, C, Chan, CC, Charleson, S, Cromlish, W, Ethier, D, Evans, JF, Ford-Hutchinson, AW, Gauthier, JY, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, GP, Ouellet, M, Percival, MD, Perrier, H, Riendeau, D, Rodger, I, and Zamboni, R. "The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor." Bioorganic & Medicinal Chemistry Letters 9.13 (July 1999): 1773-1778. Full Text

Lindsay, GA, Kolega, RR, Roberts, MJ, Uyeda, HT, Therien, M, and Herman, WN. "Multilayer χ(2) films from porphyrin chromophores by LBK processing." Proceedings of SPIE - The International Society for Optical Engineering 3796 (1999): 299-307.

Hyslop, AG, Kellett, MA, Iovine, PM, and Therien, MJ. "Suzuki porphyrins: New synthons for the fabrication of porphyrin- containing supramolecular assemblies [6]." Journal of the American Chemical Society 120.48 (1998): 12676-12677. Full Text

Kumble, R, Palese, S, Lin, VS-Y, Therien, MJ, and Hochstrasser, RM. "Ultrafast dynamics of highly conjugated porphyrin arrays." Journal of the American Chemical Society 120.44 (1998): 11489-11498. Full Text

Karki, L, Vance, FW, Hupp, JT, LeCours, SM, and Therien, MJ. "Electronic stark effect studies of a porphyrin-based push-pull chromophore displaying a large first hyperpolarizability: State-specific contributions to β." Journal of the American Chemical Society 120.11 (1998): 2606-2611. Full Text

Chan, CC, Panneton, M, Taylor, AM, Therien, M, and Rodger, IW. "A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates." European journal of pharmacology 327.2-3 (May 1997): 221-225. Full Text