Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

West, GM, Thompson, JW, Soderblom, EJ, Dubois, LG, Dearmond, PD, Moseley, MA, and Fitzgerald, MC. "Mass spectrometry-based thermal shift assay for protein-ligand binding analysis." Anal Chem 82.13 (July 1, 2010): 5573-5581. Full Text Open Access Copy

West, GM, Tucker, CL, Xu, T, Park, SK, Han, X, Yates, JR, and Fitzgerald, MC. "Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements." Proc Natl Acad Sci U S A 107.20 (May 18, 2010): 9078-9082. Full Text

Xu, Y, Schmitt, S, Tang, L, Jakob, U, and Fitzgerald, MC. "Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates." Biochemistry 49.6 (February 16, 2010): 1346-1353. Full Text Open Access Copy

DeArmond, PD, West, GM, Anbalagan, V, and Fitzgerald, MC. "Discovery of Novel Cyclophilin A Ligands Using an H/D Exchange- and Mass Spectrometry-Based Strategy. Journal of Biomolecular Screening." Journal of Biomolecular Screening 15.9 (2010): 1051-1062. (Academic Article)

Hopper, ED, Pittman, AMC, Tucker, CL, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection." Anal Chem 81.16 (August 15, 2009): 6860-6867. Full Text

Fitzgerald, MC, and West, GM. "Painting Proteins with Covalent Labels: What's In the Picture? (Reprinted from J. Am. Soc. Mass Spectrom, vol 20, pg 1193-1206, 2009)." JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 20.7 (July 2009): 1193-1206.

Fitzgerald, MC, and West, GM. "Painting proteins with covalent labels: what's in the picture?." J Am Soc Mass Spectrom 20.6 (June 2009): 1193-1206. Full Text

Siburt, CJP, Roulhac, PL, Weaver, KD, Noto, JM, Mietzner, TA, Cornelissen, CN, Fitzgerald, MC, and Crumbliss, AL. "Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae." Metallomics 1.3 (2009): 249-255. Full Text

Hopper, ED, Pittman, AMC, Fitzgerald, MC, and Tucker, CL. "In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase." The Journal of Biological Chemistry 283.45 (November 2008): 30493-30502. Full Text

Hopper, ED, Roulhac, PL, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection." J Am Soc Mass Spectrom 19.9 (September 2008): 1303-1311. Full Text