Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Tran, DT, Banerjee, S, Alayash, AI, Crumbliss, AL, and Fitzgerald, MC. "Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry." Anal Chem 84.3 (February 7, 2012): 1653-1660. Full Text

Reichmann, D, Xu, Y, Cremers, CM, Ilbert, M, Mittelman, R, Fitzgerald, MC, and Jakob, U. "Order out of disorder: Working cycle of an intrinsically unfolded chaperone." Cell 148.5 (2012): 947-957. Full Text

Dearmond, PD, Xu, Y, Strickland, EC, Daniels, KG, and Fitzgerald, MC. "Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach." J Proteome Res 10.11 (November 4, 2011): 4948-4958. Full Text

DeArmond, PD, West, GM, Huang, H-T, and Fitzgerald, MC. "Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures." J Am Soc Mass Spectrom 22.3 (March 2011): 418-430. Full Text

Xu, Y, Falk, IN, Hallen, MA, and Fitzgerald, MC. "Xu, Y., Falk, I.N., Hallen, M.A., and Fitzgerald, M.C." Analytical Chemistry 83 (2011): 3555-3562. (Academic Article)

Dearmond, PD, West, GM, Anbalagan, V, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy." J Biomol Screen 15.9 (October 2010): 1051-1062. Full Text

Kim, H, Baker, JB, Park, Y, Park, H-B, DeArmond, PD, Kim, SH, Fitzgerald, MC, Lee, D-S, and Hong, J. "Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B." Chem Asian J 5.8 (August 2, 2010): 1902-1910. Full Text

West, GM, Thompson, JW, Soderblom, EJ, Dubois, LG, Dearmond, PD, Moseley, MA, and Fitzgerald, MC. "Mass spectrometry-based thermal shift assay for protein-ligand binding analysis." Anal Chem 82.13 (July 1, 2010): 5573-5581. Full Text Open Access Copy

West, GM, Tucker, CL, Xu, T, Park, SK, Han, X, Yates, JR, and Fitzgerald, MC. "Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements." Proc Natl Acad Sci U S A 107.20 (May 18, 2010): 9078-9082. Full Text