Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Adhikari, J, West, GM, and Fitzgerald, MC. "Global analysis of protein folding thermodynamics for disease state characterization." Journal of proteome research 14.5 (May 2015): 2287-2297. Full Text

Adhikari, J, and Fitzgerald, MC. "SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding." Journal of the American Society for Mass Spectrometry 25.12 (December 2014): 2073-2083. Full Text

Xu, Y, Strickland, EC, and Fitzgerald, MC. "Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol." Analytical chemistry 86.14 (July 2014): 7041-7048. Full Text

Geer, MA, and Fitzgerald, MC. "Energetics-based methods for protein folding and stability measurements." Annual review of analytical chemistry (Palo Alto, Calif.) 7 (January 2014): 209-228. (Review) Full Text

Strickland, EC, Geer, MA, Hong, J, and Fitzgerald, MC. "False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform." J Am Soc Mass Spectrom 25.1 (January 2014): 132-140. Full Text

Strickland, EC, Geer, MA, Tran, DT, Adhikari, J, West, GM, DeArmond, PD, Xu, Y, and Fitzgerald, MC. "Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation." Nat Protoc 8.1 (January 2013): 148-161. Full Text

Banerjee, S, Siburt, CJP, Mistry, S, Noto, JM, DeArmond, P, Fitzgerald, MC, Lambert, LA, Cornelissen, CN, and Crumbliss, AL. "Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport." Metallomics 4.4 (April 2012): 361-372. Full Text

Tran, DT, Banerjee, S, Alayash, AI, Crumbliss, AL, and Fitzgerald, MC. "Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry." Anal Chem 84.3 (February 7, 2012): 1653-1660. Full Text

Reichmann, D, Xu, Y, Cremers, CM, Ilbert, M, Mittelman, R, Fitzgerald, MC, and Jakob, U. "Order out of disorder: Working cycle of an intrinsically unfolded chaperone." Cell 148.5 (2012): 947-957. Full Text