Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Strickland, EC, Geer, MA, Tran, DT, Adhikari, J, West, GM, DeArmond, PD, Xu, Y, and Fitzgerald, MC. "Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation." Nat Protoc 8.1 (January 2013): 148-161. Full Text

Banerjee, S, Siburt, CJP, Mistry, S, Noto, JM, DeArmond, P, Fitzgerald, MC, Lambert, LA, Cornelissen, CN, and Crumbliss, AL. "Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport." Metallomics 4.4 (April 2012): 361-372. Full Text

Reichmann, D, Xu, Y, Cremers, CM, Ilbert, M, Mittelman, R, Fitzgerald, MC, and Jakob, U. "Order out of disorder: working cycle of an intrinsically unfolded chaperone." Cell 148.5 (March 2012): 947-957. Full Text

Tran, DT, Banerjee, S, Alayash, AI, Crumbliss, AL, and Fitzgerald, MC. "Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry." Anal Chem 84.3 (February 7, 2012): 1653-1660. Full Text

Dearmond, PD, Xu, Y, Strickland, EC, Daniels, KG, and Fitzgerald, MC. "Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach." J Proteome Res 10.11 (November 4, 2011): 4948-4958. Full Text

DeArmond, PD, West, GM, Huang, H-T, and Fitzgerald, MC. "Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures." J Am Soc Mass Spectrom 22.3 (March 2011): 418-430. Full Text

Xu, Y, Falk, IN, Hallen, MA, and Fitzgerald, MC. "Xu, Y., Falk, I.N., Hallen, M.A., and Fitzgerald, M.C." Analytical Chemistry 83 (2011): 3555-3562. (Academic Article)

Dearmond, PD, West, GM, Anbalagan, V, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy." J Biomol Screen 15.9 (October 2010): 1051-1062. Full Text

Kim, H, Baker, JB, Park, Y, Park, H-B, DeArmond, PD, Kim, SH, Fitzgerald, MC, Lee, D-S, and Hong, J. "Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B." Chem Asian J 5.8 (August 2, 2010): 1902-1910. Full Text