Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Geer, MA, and Fitzgerald, MC. "Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique." Journal of the American Society for Mass Spectrometry 27.2 (February 2016): 233-243. Full Text

Kwon, D-Y, Lee, HE, Weitzel, DH, Park, K, Lee, SH, Lee, C-T, Stephenson, TN, Park, H, Fitzgerald, MC, Chi, J-T, Mook, RA, Dewhirst, MW, Lee, YM, and Hong, J. "Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition." Journal of medicinal chemistry 58.19 (October 2015): 7659-7671. Full Text

Adhikari, J, West, GM, and Fitzgerald, MC. "Global analysis of protein folding thermodynamics for disease state characterization." Journal of proteome research 14.5 (May 2015): 2287-2297. Full Text

Adhikari, J, and Fitzgerald, MC. "SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding." Journal of the American Society for Mass Spectrometry 25.12 (December 2014): 2073-2083. Full Text

Xu, Y, Strickland, EC, and Fitzgerald, MC. "Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol." Analytical chemistry 86.14 (July 2014): 7041-7048. Full Text

Geer, MA, and Fitzgerald, MC. "Energetics-based methods for protein folding and stability measurements." Annual review of analytical chemistry (Palo Alto, Calif.) 7 (January 2014): 209-228. (Review) Full Text

Strickland, EC, Geer, MA, Hong, J, and Fitzgerald, MC. "False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform." J Am Soc Mass Spectrom 25.1 (January 2014): 132-140. Full Text

Strickland, EC, Geer, MA, Tran, DT, Adhikari, J, West, GM, DeArmond, PD, Xu, Y, and Fitzgerald, MC. "Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation." Nat Protoc 8.1 (January 2013): 148-161. Full Text

Banerjee, S, Siburt, CJP, Mistry, S, Noto, JM, DeArmond, P, Fitzgerald, MC, Lambert, LA, Cornelissen, CN, and Crumbliss, AL. "Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport." Metallomics 4.4 (April 2012): 361-372. Full Text