Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Tang, L, Hopper, ED, Tong, Y, Sadowsky, JD, Peterson, KJ, Gellman, SH, and Fitzgerald, MC. "H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding." Anal Chem 79.15 (August 1, 2007): 5869-5877. Full Text

Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, and McCafferty, DG. "Analysis of Active Site Residues in the Staphylococcus aureus Transpeptidase SrtA Mutational." Biochemistry 46 (2007): 7269-7278. (Academic Article)

Williams, JC, Roulhac, PL, Roy, AG, Vallee, RB, Fitzgerald, MC, and Hendrickson, WA. "Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex." Proceedings of the National Academy of Sciences of the United States of America 104.24 (2007): 10028-10033. Full Text

Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, and McCafferty, DG. "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA." Biochemistry 46.24 (2007): 7269-7278. Full Text

Dai, SY, and Fitzgerald, MC. "A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions." Biochemistry 45.42 (October 24, 2006): 12890-12897. Full Text

Yang, X, Wang, M, and Fitzgerald, MC. "Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states." J Mol Biol 363.2 (October 20, 2006): 506-519. Full Text

Yang, X, and Fitzgerald, MC. "Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus." Bioorg Chem 34.3 (June 2006): 131-141. Full Text

Wang, M, Wales, TE, and Fitzgerald, MC. "Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold." Proc Natl Acad Sci U S A 103.8 (February 21, 2006): 2600-2604. Full Text

Cisneros, GA, Wang, M, Silinski, P, Fitzgerald, MC, and Yang, W. "Theoretical and experimental determination on two substrates turned over by 4-oxalocrotonate tautomerase." J Phys Chem A 110.2 (January 19, 2006): 700-708. Full Text