Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

DeArmond, PD, West, GM, Huang, H-T, and Fitzgerald, MC. "Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures." J Am Soc Mass Spectrom 22.3 (March 2011): 418-430. Full Text

Xu, Y, Falk, IN, Hallen, MA, and Fitzgerald, MC. "Xu, Y., Falk, I.N., Hallen, M.A., and Fitzgerald, M.C." Analytical Chemistry 83 (2011): 3555-3562. (Academic Article)

Dearmond, PD, West, GM, Anbalagan, V, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy." J Biomol Screen 15.9 (October 2010): 1051-1062. Full Text

Kim, H, Baker, JB, Park, Y, Park, H-B, DeArmond, PD, Kim, SH, Fitzgerald, MC, Lee, D-S, and Hong, J. "Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B." Chem Asian J 5.8 (August 2, 2010): 1902-1910. Full Text

West, GM, Thompson, JW, Soderblom, EJ, Dubois, LG, Dearmond, PD, Moseley, MA, and Fitzgerald, MC. "Mass spectrometry-based thermal shift assay for protein-ligand binding analysis." Anal Chem 82.13 (July 1, 2010): 5573-5581. Full Text Open Access Copy

West, GM, Tucker, CL, Xu, T, Park, SK, Han, X, Yates, JR, and Fitzgerald, MC. "Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements." Proc Natl Acad Sci U S A 107.20 (May 18, 2010): 9078-9082. Full Text

Xu, Y, Schmitt, S, Tang, L, Jakob, U, and Fitzgerald, MC. "Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates." Biochemistry 49.6 (February 16, 2010): 1346-1353. Full Text Open Access Copy

DeArmond, PD, West, GM, Anbalagan, V, and Fitzgerald, MC. "Discovery of Novel Cyclophilin A Ligands Using an H/D Exchange- and Mass Spectrometry-Based Strategy. Journal of Biomolecular Screening." Journal of Biomolecular Screening 15.9 (2010): 1051-1062. (Academic Article)

Hopper, ED, Pittman, AMC, Tucker, CL, Campa, MJ, Patz, EF, and Fitzgerald, MC. "Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection." Anal Chem 81.16 (August 15, 2009): 6860-6867. Full Text

Fitzgerald, MC, and West, GM. "Painting Proteins with Covalent Labels: What's In the Picture? (Reprinted from J. Am. Soc. Mass Spectrom, vol 20, pg 1193-1206, 2009)." JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 20.7 (July 2009): 1193-1206. Full Text