Faculty Profiles

Kenichi Yokoyama
Assistant Professor of Biochemistry
Office: 
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
Phone: 
(919) 684-8848

Overview

Education:

Ph.D., Tokyo Institute of Technology 2008

Ando, N, Brignole, EJ, Zimanyi, CM, Funk, MA, Yokoyama, K, Asturias, FJ, Stubbe, J, and Drennan, CL. "Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase." Proceedings of the National Academy of Sciences of the United States of America 108.52 (2011): 21046-21051. Full Text

Yokoyama, K, Smith, AA, Corzilius, B, Griffin, RG, and Stubbe, J. "Equilibration of tyrosyl radicals (Y 356·, Y 731·, Y 730·) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase." Journal of the American Chemical Society 133.45 (2011): 18420-18432. Full Text

Yokoyama, K, Uhlin, U, and Stubbe, J. "A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase." Journal of the American Chemical Society 132.43 (2010): 15368-15379. Full Text

Yokoyama, K, Uhlin, U, and Stubbe, J. "Site-specific incorporation of 3-nitrotyrosine as a probe of p k a perturbation of redox-active tyrosines in ribonucleotide reductase." Journal of the American Chemical Society 132.24 (2010): 8385-8397. Full Text

Minnihan, EC, Yokoyama, K, and Stubbe, J. "Unnatural amino acids: better than the real things?." F1000 Biology Reports (2009). Full Text

Kudo, F, Kawashima, T, Yokoyama, K, and Eguchi, T. "Enzymatic preparation of neomycin C from ribostamycin." Journal of Antibiotics 62.11 (2009): 643-646. Full Text

Artin, E, Wang, J, Lohman, GJS, Yokoyama, K, Yu, G, Griffin, RG, Bar, G, and Stubbe, J. "Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5′-diphosphate in the presence or absence of reductant." Biochemistry 48.49 (2009): 11622-11629. Full Text

Yokoyama, K, Ohmori, D, Kudo, F, and Eguchi, T. "Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy." Biochemistry 47.34 (2008): 8950-8960. Full Text

Yokoyama, K, Numakura, M, Kudo, F, Ohmori, D, and Eguchi, T. "Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin." Journal of the American Chemical Society 129.49 (2007): 15147-15155. Full Text

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