Faculty Profiles

Kenichi Yokoyama
Assistant Professor of Biochemistry
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
(919) 684-8848



Ph.D., Tokyo Institute of Technology 2008

Yokoyama, K. "Radical Breakthroughs in Natural Product and Cofactor Biosynthesis." Biochemistry 57.4 (January 2018): 390-402. Full Text

Ravichandran, K, Minnihan, EC, Lin, Q, Yokoyama, K, Taguchi, AT, Shao, J, Nocera, DG, and Stubbe, J. "Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase." Biochemistry 56.6 (February 2017): 856-868. Full Text

Lilla, EA, and Yokoyama, K. "Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes." Nature chemical biology 12.11 (November 2016): 905-907. Full Text

Chen, L, Li, Y, Yue, Q, Loksztejn, A, Yokoyama, K, Felix, EA, Liu, X, Zhang, N, An, Z, and Bills, GF. "Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity." ACS chemical biology 11.10 (October 2016): 2724-2733. Full Text

Hover, BM, Lilla, EA, and Yokoyama, K. "Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue." Biochemistry 54.49 (December 2015): 7229-7236. Full Text

Yokoyama, K, and Leimkühler, S. "The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria." Biochimica et biophysica acta 1853.6 (June 2015): 1335-1349. (Review) Full Text

Hover, BM, Tonthat, NK, Schumacher, MA, and Yokoyama, K. "Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis." Proceedings of the National Academy of Sciences of the United States of America 112.20 (May 4, 2015): 6347-6352. Full Text

Hover, BM, and Yokoyama, K. "C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis." Journal of the American Chemical Society 137.9 (March 2, 2015): 3352-3359. Full Text

Wei, Y, Mathies, G, Yokoyama, K, Chen, J, Griffin, RG, and Stubbe, J. "A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase." Journal of the American Chemical Society 136.25 (June 17, 2014): 9001-9013. Full Text

Hover, BM, Loksztejn, A, Ribeiro, AA, and Yokoyama, K. "Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis." J Am Chem Soc 135.18 (May 8, 2013): 7019-7032. Full Text