Faculty Profiles

Ken Yokoyama
Assistant Professor of Chemistry
Office: 
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
Phone: 
(919) 684-8848

Overview

Education:

Ph.D., Tokyo Institute of Technology 2008

Byer, AS, Yang, H, McDaniel, EC, Kathiresan, V, Impano, S, Pagnier, A, Watts, H, Denler, C, Vagstad, AL, Piel, J, Duschene, KS, Shepard, EM, Shields, TP, Scott, LG, Lilla, EA, Yokoyama, K, Broderick, WE, Hoffman, BM, and Broderick, JB. "Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis." Journal of the American Chemical Society 140.28 (July 6, 2018): 8634-8638. Full Text

Yokoyama, K, and Lilla, EA. "C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products." Natural Product Reports 35.7 (July 2018): 660-694. (Review) Full Text

Yokoyama, K. "Radical Breakthroughs in Natural Product and Cofactor Biosynthesis." Biochemistry 57.4 (January 2018): 390-402. (Review) Full Text

Pang, H, and Yokoyama, K. "Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis." Methods in Enzymology 606 (January 2018): 485-522. Full Text

Ravichandran, K, Minnihan, EC, Lin, Q, Yokoyama, K, Taguchi, AT, Shao, J, Nocera, DG, and Stubbe, J. "Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase." Biochemistry 56.6 (February 2, 2017): 856-868. Full Text

Lilla, EA, and Yokoyama, K. "Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes." Nature Chemical Biology 12.11 (November 2016): 905-907. Full Text

Chen, L, Li, Y, Yue, Q, Loksztejn, A, Yokoyama, K, Felix, EA, Liu, X, Zhang, N, An, Z, and Bills, GF. "Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity." Acs Chemical Biology 11.10 (October 2016): 2724-2733. Full Text

Hover, BM, Lilla, EA, and Yokoyama, K. "Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue." Biochemistry 54.49 (December 2015): 7229-7236. Full Text

Yokoyama, K, and Leimkühler, S. "The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria." Biochimica et biophysica acta 1853.6 (June 2015): 1335-1349. (Review) Full Text

Hover, BM, Tonthat, NK, Schumacher, MA, and Yokoyama, K. "Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis." Proceedings of the National Academy of Sciences of the United States of America 112.20 (May 4, 2015): 6347-6352. Full Text

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