Faculty Profiles

Katherine J. Franz
Alexander F. Hehmeyer Professor of Chemistry
2103 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1541



Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Helsel, ME, and Franz, KJ. "Pharmacological activity of metal binding agents that alter copper bioavailability." Dalton transactions (Cambridge, England : 2003) 44.19 (May 2015): 8760-8770. Full Text

Bureš, J, Jansová, H, Stariat, J, Filipský, T, Mladěnka, P, Šimůnek, T, Kučera, R, Klimeš, J, Wang, Q, Franz, KJ, and Kovaříková, P. "LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)." Journal of pharmaceutical and biomedical analysis 105 (February 2015): 55-63. Full Text

Alies, B, Wiener, JD, and Franz, KJ. "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity." Chem. Sci. 6.6 (2015): 3606-3610. Full Text

Franks, AT, Wang, Q, and Franz, KJ. "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress." Bioorganic and Medicinal Chemistry Letters 25.21 (2015): 4843-4847. Full Text

Franks, AT, and Franz, KJ. "A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting." Chemical communications (Cambridge, England) 50.77 (October 2014): 11317-11320. Full Text

Safi, R, Nelson, ER, Chitneni, SK, Franz, KJ, George, DJ, Zalutsky, MR, and McDonnell, DP. "Copper signaling axis as a target for prostate cancer therapeutics." Cancer research 74.20 (October 2014): 5819-5831. Full Text Open Access Copy

Jansová, H, Macháček, M, Wang, Q, Hašková, P, Jirkovská, A, Potůčková, E, Kielar, F, Franz, KJ, and Simůnek, T. "Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury." Free radical biology & medicine 74 (September 2014): 210-221. Full Text

Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. "Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection." Chemistry & biology 21.8 (August 2014): 977-987. Full Text

Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. "Innate immune cell activation of a copper-dependent anti-cryptococcal agent." MYCOSES 57 (May 2014): 56-57.

Franks, AT, Peng, D, Yang, W, and Franz, KJ. "Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties." Inorganic chemistry 53.3 (February 2014): 1397-1405. Full Text