Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Dethoff, EA, Hansen, AL, Zhang, Q, and Al-Hashimi, HM. "Variable helix elongation as a tool to modulate RNA alignment and motional couplings." Journal of magnetic resonance (San Diego, Calif. : 1997) 202.1 (January 2010): 117-121. Full Text

Buer, BC, de la Salud-Bea, R, Al Hashimi, HM, and Marsh, ENG. "Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects." Biochemistry 48.45 (November 2009): 10810-10817. Full Text

Zhang, Q, and Al-Hashimi, HM. "Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition." RNA (New York, N.Y.) 15.11 (November 2009): 1941-1948. (Review) Full Text

Stelzer, AC, Frank, AT, Bailor, MH, Andricioaei, I, and Al-Hashimi, HM. "Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs." Methods (San Diego, Calif.) 49.2 (October 2009): 167-173. Full Text

Al-Hashimi, HM. "Structural biology: Aerial view of the HIV genome." Nature 460.7256 (August 2009): 696-698. Full Text

Frank, AT, Stelzer, AC, Al-Hashimi, HM, and Andricioaei, I. "Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition." Nucleic acids research 37.11 (June 2009): 3670-3679. Full Text

Buhrlage, SJ, Bates, CA, Rowe, SP, Minter, AR, Brennan, BB, Majmudar, CY, Wemmer, DE, Al-Hashimi, H, and Mapp, AK. "Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors." ACS Chem Biol 4.5 (May 15, 2009): 335-344. Full Text

Fisher, CK, and Al-Hashimi, HM. "Approximate reconstruction of continuous spatially complex domain motions by multialignment NMR residual dipolar couplings." The journal of physical chemistry. B 113.18 (May 2009): 6173-6176. (Letter) Full Text

Hansen, AL, Nikolova, EN, Casiano-Negroni, A, and Al-Hashimi, HM. "Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy." Journal of the American Chemical Society 131.11 (March 2009): 3818-3819. Full Text

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