Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry



Ph.D., Yale University 2000

Bailor, MH, Mustoe, AM, Brooks, CL, and Al-Hashimi, HM. "Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation." Current opinion in structural biology 21.3 (June 2011): 296-305. (Review) Full Text

Horowitz, S, Yesselman, JD, Al-Hashimi, HM, and Trievel, RC. "Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9." The Journal of biological chemistry 286.21 (May 2011): 18658-18663. Full Text

Bothe, JR, Lowenhaupt, K, and Al-Hashimi, HM. "Sequence-specific B-DNA flexibility modulates Z-DNA formation." Journal of the American Chemical Society 133.7 (February 2011): 2016-2018. Full Text

Nikolova, EN, Kim, E, Wise, AA, O'Brien, PJ, Andricioaei, I, and Al-Hashimi, HM. "Transient Hoogsteen base pairs in canonical duplex DNA." Nature 470.7335 (February 2011): 498-502. Full Text

Dethoff, EA, and Al-Hashimi, HM. "A rare example of lock-and-key RNA recognition." Journal of molecular biology 404.4 (December 2010): 553-554. Full Text

Al-Hashimi, HM. "Biochemistry. Exciting structures." Science (New York, N.Y.) 329.5997 (September 2010): 1295-1296. Full Text

Nikolova, EN, and Al-Hashimi, HM. "Thermodynamics of RNA melting, one base pair at a time." RNA 16.9 (September 2010): 1687-1691. Full Text

Stelzer, AC, Kratz, JD, Zhang, Q, and Al-Hashimi, HM. "RNA dynamics by design: biasing ensembles towards the ligand-bound state." Angewandte Chemie (International ed. in English) 49.33 (August 2010): 5731-5733. Full Text

Buer, BC, Chugh, J, Al-Hashimi, HM, and Marsh, ENG. "Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer." Biochemistry 49.27 (July 2010): 5760-5765. Full Text

Koutmou, KS, Casiano-Negroni, A, Getz, MM, Pazicni, S, Andrews, AJ, Penner-Hahn, JE, Al-Hashimi, HM, and Fierke, CA. "NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P." Proceedings of the National Academy of Sciences of the United States of America 107.6 (February 2010): 2479-2484. Full Text