Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Eichhorn, CD, Feng, J, Suddala, KC, Walter, NG, Brooks, CL, and Al-Hashimi, HM. "Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch." Nucleic acids research 40.3 (February 2012): 1345-1355. Full Text

Mustoe, AM, Bailor, MH, Teixeira, RM, Brooks, CL, and Al-Hashimi, HM. "New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation." Nucleic acids research 40.2 (January 2012): 892-904. Full Text

Petzold, K, and Al-Hashimi, HM. "RNA structure: Adding a second dimension." Nature chemistry 3.12 (December 2011): 913-915. Full Text

Bothe, JR, Nikolova, EN, Eichhorn, CD, Chugh, J, Hansen, AL, and Al-Hashimi, HM. "Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy." Nature methods 8.11 (October 28, 2011): 919-931. (Review) Full Text

Bailor, MH, Mustoe, AM, Brooks, CL, and Al-Hashimi, HM. "3D maps of RNA interhelical junctions." Nature protocols 6.10 (September 15, 2011): 1536-1545. Full Text

Stelzer, AC, Frank, AT, Kratz, JD, Swanson, MD, Gonzalez-Hernandez, MJ, Lee, J, Andricioaei, I, Markovitz, DM, and Al-Hashimi, HM. "Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble." Nature chemical biology 7.8 (June 26, 2011): 553-559. Full Text

Bailor, MH, Mustoe, AM, Brooks, CL, and Al-Hashimi, HM. "Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation." Current opinion in structural biology 21.3 (June 2011): 296-305. (Review) Full Text

Horowitz, S, Yesselman, JD, Al-Hashimi, HM, and Trievel, RC. "Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9." The Journal of biological chemistry 286.21 (May 2011): 18658-18663. Full Text

Bothe, JR, Lowenhaupt, K, and Al-Hashimi, HM. "Sequence-specific B-DNA flexibility modulates Z-DNA formation." Journal of the American Chemical Society 133.7 (February 2011): 2016-2018. Full Text

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