Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Bothe, JR, Lowenhaupt, K, and Al-Hashimi, HM. "Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation." Biochemistry 51.34 (August 17, 2012): 6871-6879. Full Text

Nikolova, EN, Gottardo, FL, and Al-Hashimi, HM. "Probing transient Hoogsteen hydrogen bonds in canonical duplex DNA using NMR relaxation dispersion and single-atom substitution." Journal of the American Chemical Society 134.8 (February 16, 2012): 3667-3670. Full Text

Dethoff, EA, Chugh, J, Mustoe, AM, and Al-Hashimi, HM. "Functional complexity and regulation through RNA dynamics." Nature 482.7385 (February 15, 2012): 322-330. (Review) Full Text

Eichhorn, CD, Feng, J, Suddala, KC, Walter, NG, Brooks, CL, and Al-Hashimi, HM. "Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch." Nucleic acids research 40.3 (February 2012): 1345-1355. Full Text

Mustoe, AM, Bailor, MH, Teixeira, RM, Brooks, CL, and Al-Hashimi, HM. "New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation." Nucleic acids research 40.2 (January 2012): 892-904. Full Text

Petzold, K, and Al-Hashimi, HM. "RNA structure: Adding a second dimension." Nature chemistry 3.12 (December 2011): 913-915. Full Text

Bothe, JR, Nikolova, EN, Eichhorn, CD, Chugh, J, Hansen, AL, and Al-Hashimi, HM. "Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy." Nature methods 8.11 (October 28, 2011): 919-931. (Review) Full Text

Bailor, MH, Mustoe, AM, Brooks, CL, and Al-Hashimi, HM. "3D maps of RNA interhelical junctions." Nature protocols 6.10 (September 15, 2011): 1536-1545. Full Text

Stelzer, AC, Frank, AT, Kratz, JD, Swanson, MD, Gonzalez-Hernandez, MJ, Lee, J, Andricioaei, I, Markovitz, DM, and Al-Hashimi, HM. "Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble." Nature chemical biology 7.8 (June 26, 2011): 553-559. Full Text

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