Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Nikolova, EN, Goh, GB, Brooks, CL, and Al-Hashimi, HM. "Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA." Journal of the American Chemical Society 135.18 (May 2013): 6766-6769. Full Text

Salmon, L, Bascom, G, Andricioaei, I, and Al-Hashimi, HM. "A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed." Journal of the American Chemical Society 135.14 (April 2013): 5457-5466. Full Text

Frank, AT, Horowitz, S, Andricioaei, I, and Al-Hashimi, HM. "Utility of 1H NMR chemical shifts in determining RNA structure and dynamics." The journal of physical chemistry. B 117.7 (February 7, 2013): 2045-2052. Full Text

Eichhorn, CD, Yang, S, and Al-Hashimi, HM. "Characterising RNA dynamics using NMR residual dipolar couplings." RSC Biomolecular Sciences (December 1, 2012): 184-215.

Dethoff, EA, Petzold, K, Chugh, J, Casiano-Negroni, A, and Al-Hashimi, HM. "Visualizing transient low-populated structures of RNA." Nature 491.7426 (November 2012): 724-728. Full Text

Prevette, LE, Nikolova, EN, Al-Hashimi, HM, and Banaszak Holl, MM. "Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release." Molecular pharmaceutics 9.9 (September 2012): 2743-2749. Full Text

Bothe, JR, Lowenhaupt, K, and Al-Hashimi, HM. "Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation." Biochemistry 51.34 (August 17, 2012): 6871-6879. Full Text

Nikolova, EN, Gottardo, FL, and Al-Hashimi, HM. "Probing transient Hoogsteen hydrogen bonds in canonical duplex DNA using NMR relaxation dispersion and single-atom substitution." Journal of the American Chemical Society 134.8 (February 16, 2012): 3667-3670. Full Text

Dethoff, EA, Chugh, J, Mustoe, AM, and Al-Hashimi, HM. "Functional complexity and regulation through RNA dynamics." Nature 482.7385 (February 15, 2012): 322-330. (Review) Full Text

Pages