Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Nikolova, EN, Zhou, H, Gottardo, FL, Alvey, HS, Kimsey, IJ, and Al-Hashimi, HM. "A historical account of Hoogsteen base-pairs in duplex DNA." Biopolymers 99.12 (December 2013): 955-968. Full Text

Horowitz, S, Dirk, LMA, Yesselman, JD, Nimtz, JS, Adhikari, U, Mehl, RA, Scheiner, S, Houtz, RL, Al-Hashimi, HM, and Trievel, RC. "Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases." Journal of the American Chemical Society 135.41 (October 7, 2013): 15536-15548. Full Text

Lee, J, Vogt, CE, McBrairty, M, and Al-Hashimi, HM. "Influence of dimethylsulfoxide on RNA structure and ligand binding." Analytical chemistry 85.20 (October 2013): 9692-9698. Full Text

Nikolova, EN, Goh, GB, Brooks, CL, and Al-Hashimi, HM. "Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA." Journal of the American Chemical Society 135.18 (May 2013): 6766-6769. Full Text

Salmon, L, Bascom, G, Andricioaei, I, and Al-Hashimi, HM. "A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed." Journal of the American Chemical Society 135.14 (April 2013): 5457-5466. Full Text

Frank, AT, Horowitz, S, Andricioaei, I, and Al-Hashimi, HM. "Utility of 1H NMR chemical shifts in determining RNA structure and dynamics." The journal of physical chemistry. B 117.7 (February 7, 2013): 2045-2052. Full Text

Eichhorn, CD, Yang, S, and Al-Hashimi, HM. "Characterising RNA dynamics using NMR residual dipolar couplings." RSC Biomolecular Sciences (December 1, 2012): 184-215.

Dethoff, EA, Petzold, K, Chugh, J, Casiano-Negroni, A, and Al-Hashimi, HM. "Visualizing transient low-populated structures of RNA." Nature 491.7426 (November 2012): 724-728. Full Text

Prevette, LE, Nikolova, EN, Al-Hashimi, HM, and Banaszak Holl, MM. "Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release." Molecular pharmaceutics 9.9 (September 2012): 2743-2749. Full Text

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